DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpp and GDF10

DIOPT Version :9

Sequence 1:	NP_477311.1	Gene:	dpp / 33432	FlyBaseID:	FBgn0000490	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_004953.1	Gene:	GDF10 / 2662	HGNCID:	4215	Length:	478	Species:	Homo sapiens

Alignment Length:	520	Identity:	124/520 - (23%)
Similarity:	198/520 - (38%)	Gaps:	176/520 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 LVLDREVASIN-------VPANAKAIIAEQGPSTYSKEALIKDKLKPDPSTLVEIEKSLLSLFNM 236
            |:|.|:||..:       :||.|..:..::....:..:|..  .|.|....:|.:.
Human    25 LLLLRDVAGSHRAPAWSALPAAADGLQGDRDLQRHPGDAAA--TLGPSAQDMVAVH--------- 78

  Fly   237 KRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFTHKDSKIDDRFPHHH 301
                            |.:||      |..|....:||    ..||||||..:...:|.:..:
Human    79 ----------------MHRLY------EKYSRQGARPG----GGNTVRSFRARLEVVDQKAVY-- 115

  Fly   302 RFRLHFDVKSIPADEKLKAAELQLTRD------AL---------------------SQQVVASRS 339
                .|::.|:...|.:..|......:      ||                     ::|.:..||
Human   116 ----FFNLTSMQDSEMILTATFHFYSEPPRWPRALEVLCKPRAKNASGRPLPLGPPTRQHLLFRS 176

  Fly   340 SANRTRYQVLV----------------YDITRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQP 388
            .:..|..|.|:                .||:.: |:..|....|||   :.:|:|.:.     .|
Human   177 LSQNTATQGLLRGAMALAPPPRGLWQAKDISPI-VKAARRDGELLL---SAQLDSEER-----DP 232

  Fly   389 AVDRWLASPQRNYGLLVEVRTVRSLKP----------------------APHHHV--RLRRSA-- 427
            .|.|  .||...| :||....:...:|                      ||::..  |:||:|
Human   233 GVPR--PSPYAPY-ILVYANDLAISEPNSVAVTLQRYDPFPAGDPEPRAAPNNSADPRVRRAAQA 294

  Fly   428 ------------DE----AHERWQHKQ---PLLFTYTDDGRHKARSIRDVSGGEGGGKGGRN--- 470
                        ||    ||.:..||.   |..|          |:::...|.:...|.|:.
Human   295 TGPLQDNELPGLDERPPRAHAQHFHKHQLWPSPF----------RALKPRPGRKDRRKKGQEVFM 349

  Fly   471 --------KRQPRRPTRRKNHDD--TCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLA 525
                    ..:..:..|||..|:  .|.|..|.|||:|:||::||::|..:|||||.|.|.||:.
Human   350 AASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMP 414

  Fly   526 DHFNSTNHAVVQTLVNNMN--PGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR 588
            .....:|||.:|::|..:.  || :|:.||||.:::|:.:|:|::...||||.|..|:|..|.||
Human   415 KIVRPSNHATIQSIVRAVGIIPG-IPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478

Fly 589 588
Human 479 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	58/306 (19%)
dpp	NP_477311.1	TGFB	487..588	CDD:214556	44/102 (43%)
GDF10	NP_004953.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..319		10/52 (19%)
GDF10	NP_004953.1	TGF_beta	374..477	CDD:278448	44/103 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810