Protein Alignment dpp and GDF9

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_005251.1
• Gene: GDF9 / 2661
• HGNCID: 4224
• Length: 454
• Species: Homo sapiens
• Alignment Length: 493
• Identity: 108/493 - (21%)
• Similarity: 177/493 - (35%)
• Gaps: 131/493 - (26%)

  Fly   156 QASASTESHQSSSIESIFVEEPTLVLDREVASINVPANAKAIIAEQGPSTYSKEALIKDKLKPDP 220
            |.:||.|....:...|:...    :.:|:.|.: :||..|.:...:|.|         .:|:||.
Human    33 QIAASAELESGAMPWSLLQH----IDERDRAGL-LPALFKVLSVGRGGS---------PRLQPDS 83

  Fly   221 STLVEIEKSLLSLFNMKRPPKIDRSKI-----------------------IIPEPMKKLY----A 258
            ..|..::|...:....:..||.:||.:                       |:|. ::.|:    .
Human    84 RALHYMKKLYKTYATKEGIPKSNRSHLYNTVRLFTPCTRHKQAPGDQVTGILPS-VELLFNLDRI 147

  Fly   259 EIMGHELDSV---NIPKPGLLTKSANTVRSFTHKDSKIDD----RFPHHHRFRLHFDVKSIPADE 316
            ..:.|.|.||   ||......:.:...|.:...|:.|...    |.|:...|...|:.     .:
Human   148 TTVEHLLKSVLLYNINNSVSFSSAVKCVCNLMIKEPKSSSRTLGRAPYSFTFNSQFEF-----GK 207

  Fly   317 KLKAAELQLTRDALSQQVVASRS-----SANRT---------RYQVLVYDITRVGVRGQREPSYL 367
            |.|..::.:|  :|.|.:|||..     |.|.|         ..|..::::|.|      .||.:
Human   208 KHKWIQIDVT--SLLQPLVASNKRSIHMSINFTCMKDQLEHPSAQNGLFNMTLV------SPSLI 264

  Fly   368 LLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADEAHE 432
            |.      ||.|..      .|...|       |.|                |.:.|.|.....|
Human   265 LY------LNDTSA------QAYHSW-------YSL----------------HYKRRPSQGPDQE 294

  Fly   433 RWQHKQPLLFTYTDDGR---HKARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHD---------D 485
            |.....|:.....:|||   |:.|..::....|        .::|..|......:         :
Human   295 RSLSAYPVGEEAAEDGRSSHHRHRRGQETVSSE--------LKKPLGPASFNLSEYFRQFLLPQN 351

  Fly   486 TCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPK 550
            .|..|...:.||.:.||:|||||..|:..||.|.||..:...:.|..|.:||.::.......||:
Human   352 ECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPR 416

  Fly   551 ACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR 588
            ..|||.:...:::|.:....::..|.|::|....|.||
Human   417 PSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	51/266 (19%)
		TGFB	487..588	CDD:214556	31/100 (31%)
GDF9	NP_005251.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..330		6/34 (18%)
		TGF_beta	353..453	CDD:306518	31/99 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810