Protein Alignment dpp and GDF2

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_057288.1
• Gene: GDF2 / 2658
• HGNCID: 4217
• Length: 429
• Species: Homo sapiens
• Alignment Length: 413
• Identity: 121/413 - (29%)
• Similarity: 184/413 - (44%)
• Gaps: 89/413 - (21%)

  Fly   223 LVEIEKSLLSLFNMKRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFT 287
            |..::...|...|:...|..|::::..|:.|..||..   :..|....|       ::|.||||:
Human    59 LENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNR---YTSDKSTTP-------ASNIVRSFS 113

  Fly   288 HKDS---KIDDRFPHHHRFRLH---FDVKSIPADEKLKAAELQLTRDALSQQVVASRSSANRT-- 344
            .:|:   ...:.||    |:.|   |:: |||..|::..|||:|        .|:.::..:.:
Human   114 MEDAISITATEDFP----FQKHILLFNI-SIPRHEQITRAELRL--------YVSCQNHVDPSHD 165

  Fly   345 -RYQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDT----VSLDVQ----------PAVDRWL 394
             :..|::||:               ||......::|:|    ||.|:|          .||.||:
Human   166 LKGSVVIYDV---------------LDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWV 215

  Fly   395 ASPQRNYGLLVEVRTVR-----------SLKPAPH-----------HHVRLRRSADEAHERWQHK 437
            .|........:|| ||.           |:.|...           |....:.:..|..|...|:
Human   216 RSDSTKSKNKLEV-TVESHRKGCDTLDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHE 279

  Fly   438 Q-PLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHDDTCRRHSLYVDFSDVGW 501
            | .:|...:.||..:|.........:|....|....:.:|.....:|   |::.||.|:|.|:||
Human   280 QESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSH---CQKTSLRVNFEDIGW 341

  Fly   502 DDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYL 566
            |.||:||..|:||.|.|.|.|||||....|.||:|||||:...|.||.|||||||:|..:::||.
Human   342 DSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYK 406

  Fly   567 NDQSTVVLK-NYQEMTVVGCGCR 588
            :|.....|| :|:.|:|..||||
Human   407 DDMGVPTLKYHYEGMSVAECGCR 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	58/264 (22%)
		TGFB	487..588	CDD:214556	53/101 (52%)
GDF2	NP_057288.1	TGFb_propeptide	76..257	CDD:279078	50/219 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	283..308		5/24 (21%)
		TGF_beta	326..428	CDD:278448	53/104 (51%)
		Interaction with ENG. /evidence=ECO:0000269|PubMed:28564608	402..416		4/13 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810