DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpp and GDF2

DIOPT Version :10

Sequence 1:NP_477311.1 Gene:dpp / 33432 FlyBaseID:FBgn0000490 Length:588 Species:Drosophila melanogaster
Sequence 2:NP_057288.1 Gene:GDF2 / 2658 HGNCID:4217 Length:429 Species:Homo sapiens


Alignment Length:413 Identity:121/413 - (29%)
Similarity:184/413 - (44%) Gaps:89/413 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   223 LVEIEKSLLSLFNMKRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFT 287
            |..::...|...|:...|..|::::..|:.|..||..   :..|....|       ::|.||||:
Human    59 LENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNR---YTSDKSTTP-------ASNIVRSFS 113

  Fly   288 HKDS---KIDDRFPHHHRFRLH---FDVKSIPADEKLKAAELQLTRDALSQQVVASRSSANRT-- 344
            .:|:   ...:.||    |:.|   |:: |||..|::..|||:|        .|:.::..:.:  
Human   114 MEDAISITATEDFP----FQKHILLFNI-SIPRHEQITRAELRL--------YVSCQNHVDPSHD 165

  Fly   345 -RYQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDT----VSLDVQ----------PAVDRWL 394
             :..|::||:               ||......::|:|    ||.|:|          .||.||:
Human   166 LKGSVVIYDV---------------LDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWV 215

  Fly   395 ASPQRNYGLLVEVRTVR-----------SLKPAPH-----------HHVRLRRSADEAHERWQHK 437
            .|........:|| ||.           |:.|...           |....:.:..|..|...|:
Human   216 RSDSTKSKNKLEV-TVESHRKGCDTLDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHE 279

  Fly   438 Q-PLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHDDTCRRHSLYVDFSDVGW 501
            | .:|...:.||..:|.........:|....|....:.:|.....:|   |::.||.|:|.|:||
Human   280 QESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSH---CQKTSLRVNFEDIGW 341

  Fly   502 DDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYL 566
            |.||:||..|:||.|.|.|.|||||....|.||:|||||:...|.||.|||||||:|..:::||.
Human   342 DSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYK 406

  Fly   567 NDQSTVVLK-NYQEMTVVGCGCR 588
            :|.....|| :|:.|:|..||||
Human   407 DDMGVPTLKYHYEGMSVAECGCR 429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dppNP_477311.1 TGFb_propeptide 225..444 CDD:480997 58/264 (22%)
TGF_beta_DPP 480..588 CDD:381662 54/108 (50%)
GDF2NP_057288.1 TGFb_propeptide 70..217 CDD:480997 44/184 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 283..308 5/24 (21%)
TGF_beta_BMP9 325..429 CDD:381670 54/106 (51%)
Interaction with ENG. /evidence=ECO:0000269|PubMed:28564608 402..416 4/13 (31%)

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