DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpp and Bmp6

DIOPT Version :9

Sequence 1:	NP_477311.1	Gene:	dpp / 33432	FlyBaseID:	FBgn0000490	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	XP_038951315.1	Gene:	Bmp6 / 25644	RGDID:	2214	Length:	535	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	133/532 - (25%)
Similarity:	214/532 - (40%)	Gaps:	141/532 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 RSHQPKQASAST-------ESHQSSSIESIFVEEPTLVLDREVASI-NVPANAKAIIAEQGPST- 205
            |:.||...|:|:       ::|:...::            :|:.|: .:|...:.:...|.|.:
  Rat    50 RAEQPPPQSSSSGFLYRRLKTHEKREMQ------------KEILSVLGLPHRPRPLHGLQQPQSP 102

  Fly   206 ---YSKEALIKDKLKPDPSTLVEIEKSLLSLFN-----------------------------MKR 238
               ..:::....:.:|.|..|......:|.|:|                             :|:
  Rat   103 VLPQQQQSQQTAREEPPPGRLKSAPLFMLDLYNSLSKDDEEDGVSEGEGLEPESHGRASSSQLKQ 167

  Fly   239 PP-----KIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFTH---KDSKIDD 295
            |.     .::|..::.|.|         |.....:...:.......|:.|.||.:   .|.:...
  Rat   168 PSPGAAHSLNRKSLLAPGP---------GGSASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSP 223

  Fly   296 RFPHHHRFRLHFDVKSIPADEKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGVRG 360
            |..||..|:  |::..||..|.:.|||.::.:|.    ||.  |..|:| :.:.:|.:.:  ...
  Rat   224 RQRHHKEFK--FNLSQIPEGEAVTAAEFRVYKDC----VVG--SFKNQT-FLISIYQVLQ--EHQ 277

  Fly   361 QREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRR 425
            .|:....||||:.|..:....:..|:....:.|:.:||.|.||.:.|.|...|      |:..|.
  Rat   278 HRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGL------HINPRA 336

  Fly   426 SADEAHERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHD------ 484
            :.....:....|||.:..:........|:.|..|.         .:||..|....::.|
  Rat   337 AGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASS---------RRRQQSRNRSTQSQDVSRGSS 392

  Fly   485 ----------DTCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTL 539
                      ..|::|.|||.|.|:||.|||:||.||.|.||.|:|.|||..|.|:||||:||||
  Rat   393 ASDYNSSELKTACKKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTL 457

  Fly   540 VNN-----------------------------MNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLK 575
            |:.                             |||..|||.||.||:|:::::||.:|.|.|:||
  Rat   458 VSALTWLVGPGLDPVSFLTVSSHASLLEQVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILK 522

  Fly   576 NYQEMTVVGCGC 587
            .|:.|.|..|||
  Rat   523 KYRNMVVRACGC 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	53/255 (21%)
dpp	NP_477311.1	TGFB	487..588	CDD:214556	59/130 (45%)
Bmp6	XP_038951315.1	TGFb_propeptide	58..355	CDD:395559	64/334 (19%)
Bmp6	XP_038951315.1	TGF_beta_BMP6	404..535	CDD:381666	59/131 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063560at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X157
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820