Protein Alignment dpp and Gdf6

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_038554.1
• Gene: Gdf6 / 242316
• MGIID: 95689
• Length: 454
• Species: Mus musculus
• Alignment Length: 498
• Identity: 135/498 - (27%)
• Similarity: 203/498 - (40%)
• Gaps: 131/498 - (26%)

  Fly   155 KQASASTESHQSSSIESIFVEEPTLVLDREVASINVPANAKAIIAEQGPSTYSKEALIKDKLKPD 219
            :|||.|:.|..|:.::|          .::|.:           .::|....:.:...:.:..|:
Mouse    24 QQASISSSSSSSTELDS----------TKDVGN-----------RKEGKMQRTPQESAEGRTPPE 67

  Fly   220 PSTLVEIEKSLLSLFNMKRPP-------KIDRSKIIIP-EPMKKLY-----AEIMGHELDSVNIP 271
            ....   :|.|     .:|||       ...|...::| |.|..:|     ||.:|.......
Mouse    68 HGLR---QKDL-----RRRPPGQHQGQEPPGRGLRVVPHEYMLSIYKTYSIAEKLGINASFFQ-- 122

  Fly   272 KPGLLTKSANTVRSFTHKDSKIDDRFPHH--HRFRLHFDVKSIPADEKLKAAELQLTRDA----- 329
                .:|||||:.||.  |..:|| ..|.  .|.:..|||.::...|:|..|||:|.|.|
Mouse   123 ----SSKSANTITSFV--DRGLDD-LSHTPLRRQKYLFDVSTLSDKEELVGAELRLYRQAPPTPW 180

  Fly   330 ------LSQQVVASRSSANRTRYQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQP 388
                  |..|:....|.                          ||||.:|:..........:|
Mouse   181 GLPARPLHLQLFPCLSP--------------------------LLLDARTLDPQGPTQAGWEV-- 217

  Fly   389 AVDRWLA-SPQRNYGLLVEVRT-----------VRSLKPAPHHHVRLRRSADEAHERWQHKQPLL 441
             .|.|.. .||....|.:|:|.           .|:..|.....:.||........|...::.||
Mouse   218 -FDVWQGLRPQPWKQLCLELRAAWGELDAGDTGARARGPQQPPPLDLRSLGFGRRVRPPQERALL 281

  Fly   442 FTYTDDGR-------HKARSIRDVSGGEGGGKG--------------GRNKRQPRRPTRR-KNHD 484
            ..:|...|       |:.....:.:|.||....              ||.:|:....:|. |.|.
Mouse   282 VVFTRSQRKNLFTEMHEQLGSAEAAGAEGSWPAPSGSPDAGSWLPSPGRRRRRTAFASRHGKRHG 346

  Fly   485 D----TCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNP 545
            .    .|.|..|:|:|.::||||||:|||.|:||:|.|.|.|||..|...||||::|||:|:|:|
Mouse   347 KKSRLRCSRKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDP 411

  Fly   546 GKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR 588
            |..|.:|||||:|..:::||::..:.||.|.|::|.|..||||
Mouse   412 GSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	59/256 (23%)
		TGFB	487..588	CDD:214556	52/100 (52%)
Gdf6	NP_038554.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..93		13/93 (14%)
		TGFb_propeptide	75..284	CDD:279078	58/251 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	247..268		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..350		9/46 (20%)
		TGF_beta	352..453	CDD:278448	51/100 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810