Protein Alignment dpp and GDF7

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_878248.2
• Gene: GDF7 / 151449
• HGNCID: 4222
• Length: 450
• Species: Homo sapiens
• Alignment Length: 407
• Identity: 115/407 - (28%)
• Similarity: 170/407 - (41%)
• Gaps: 100/407 - (24%)

  Fly   244 RSKIIIPEP-MKKLYAEIMGHE---LDSVNIPKPGLLTKSANTVRSFTHKDSKIDDRFPHHHRFR 304
            |:..::|.. |..||..:.|..   ..:|:....|    .|:|:..||  |....|.........
Human    82 RNGSVVPHHFMMSLYRSLAGRAPAGAAAVSASGHG----RADTITGFT--DQATQDESAAETGQS 140

  Fly   305 LHFDVKSIPADEKLKAAELQLTRDALSQQVVASRSS---------ANRTRYQVLVYDITRVGVRG 360
            ..|||.|:...:::..|||::.|....:....|.:|         ....|...|:|......:.|
Human   141 FLFDVSSLNDADEVVGAELRVLRRGSPESGPGSWTSPPLLLLSTCPGAARAPRLLYSRAAEPLVG 205

  Fly   361 QREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRR 425
            ||..::                  ||..|:.|....|:......:.:|.|....|:|   :.|||
Human   206 QRWEAF------------------DVADAMRRHRREPRPPRAFCLLLRAVAGPVPSP---LALRR 249

  Fly   426 -----------SADE-----AHERWQHKQPLLFTYTDDGRHKARSI------------------- 455
                       :|:|     ...|.|.|:.|.    .:.|.:||::
Human   250 LGFGWPGGGGSAAEERAVLVVSSRTQRKESLF----REIRAQARALGAALASEPLPDPGTGTASP 310

  Fly   456 RDVSGG--------------EGGGKGGRNKRQPRRPTRRKNHDDTCRRHSLYVDFSDVGWDDWIV 506
            |.|.||              :|.| ||..:...||...|      |.|..|:|||.::||||||:
Human   311 RAVIGGRRRRRTALAGTRTAQGSG-GGAGRGHGRRGRSR------CSRKPLHVDFKELGWDDWII 368

  Fly   507 APLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQST 571
            |||.|:||:|.|.|.|||..|...||||::|||:|:|.|...|.:||||.:|..:::||::..:.
Human   369 APLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANN 433

  Fly   572 VVLKNYQEMTVVGCGCR 588
            ||.|.|::|.|..||||
Human   434 VVYKQYEDMVVEACGCR 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	48/228 (21%)
		TGFB	487..588	CDD:214556	51/100 (51%)
GDF7	NP_878248.2	TGFb_propeptide	<91..>217	CDD:279078	30/149 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	296..349		11/59 (19%)
		TGFB	352..450	CDD:214556	49/97 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810