Protein Alignment dpp and Gdf5

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_032135.2
• Gene: Gdf5 / 14563
• MGIID: 95688
• Length: 495
• Species: Mus musculus
• Alignment Length: 633
• Identity: 163/633 - (25%)
• Similarity: 245/633 - (38%)
• Gaps: 199/633 - (31%)

  Fly     3 AWLLLLAVLATFQTIVRVASTEDISQRFIAA-----------IAPVAAHIPLASASGSGSGRSGS 56
            |||.|       :.|..|....|:.||...|           ..|:|.::........|.|.:.:
Mouse    15 AWLDL-------ELICTVLGAPDLGQRTPGAKPGLTKAEAKERPPLARNVFRPGGHIYGVGATNA 72

  Fly    57 RSVGASTSTALAKAFNPFSEPASFSDSDKSHRSKTNKKPSKSDANRQFNEVHKPRTDQLENSKNK 121
            |:.|:|..|...|     .||              .|.|.:|..         |.|
Mouse    73 RAKGSSGQTQAKK-----DEP--------------RKMPPRSGG---------PET--------- 100

  Fly   122 SKQLVNKPNHNKMAVKEQRSHHKKSHHHRSHQPKQASASTESHQSSSIESIFVEEPTLVLDREVA 186
                  ||.                   .|.|.:||:|.|.:.:.
Mouse   101 ------KPG-------------------PSSQTRQAAARTVTPKG-------------------- 120

  Fly   187 SINVPANAKAIIAEQGPSTYSKEALIKDKLKPDPSTLVEIEKSLLSLFNMKRPPKIDRSKIIIPE 251
              .:|....:..|...||::    |:| |.: :|.|..|.::..       |||.|...     |
Mouse   121 --QLPGGKASSKAGSAPSSF----LLK-KTR-EPGTPREPKEPF-------RPPPITPH-----E 165

  Fly   252 PMKKLYAEIMGHEL----DSVNIPKPGLLTKSANTVRSFTHKDSKIDDRFPHHHRFRLHFDVKSI 312
            .|..||..:...:.    .||.: :.||    |||:.||..|..  |||.|...:.|..||:.::
Mouse   166 YMLSLYRTLSDADRKGGNSSVKL-EAGL----ANTITSFIDKGQ--DDRGPAVRKQRYVFDISAL 223

  Fly   313 PADEKLKAAELQLTR----DALSQQVVAS-------RSSANRTRYQVLVYDITRV-GVRGQREPS 365
            ..| .|..|||::.|    |.....|.:|       .||....|....:.|:..| |:.|.   .
Mouse   224 EKD-GLLGAELRILRKKPLDVAKPAVPSSGRVAQLKLSSCPSGRQPAALLDVRSVPGLDGS---G 284

  Fly   366 YLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADEA 430
            :.:.|...:..|..::..|.::  ::.|      ..|..|::|           .:...|:|.:.
Mouse   285 WEVFDIWKLFRNFKNSAQLCLE--LEAW------ERGRAVDLR-----------GLGFERTARQV 330

  Fly   431 HERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRN--------------------KRQPR 475
            ||:     .|...:   ||.|.   ||:...|...:.|::                    .||.:
Mouse   331 HEK-----ALFLVF---GRTKK---RDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLANRQGK 384

  Fly   476 RPTRRKNHDDTCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLV 540
            ||:  ||....|.|.:|:|:|.|:||||||:|||.|:|::|.|.|.|||..|...|||||:|||:
Mouse   385 RPS--KNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLM 447

  Fly   541 NNMNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR 588
            |:|:|...|..|||||:|..:::|:::..:.||.|.|::|.|..||||
Mouse   448 NSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	54/234 (23%)
		TGFB	487..588	CDD:214556	51/100 (51%)
Gdf5	NP_032135.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..162		41/228 (18%)
		TGFb_propeptide	139..338	CDD:279078	59/247 (24%)
		TGFB	394..495	CDD:214556	51/100 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810