DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpp and Gdf10

DIOPT Version :9

Sequence 1:	NP_477311.1	Gene:	dpp / 33432	FlyBaseID:	FBgn0000490	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_665684.2	Gene:	Gdf10 / 14560	MGIID:	95684	Length:	476	Species:	Mus musculus

Alignment Length:	422	Identity:	102/422 - (24%)
Similarity:	170/422 - (40%)	Gaps:	115/422 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 STLVEIEKSLLSLFNM-KRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVR 284
            :::.:.|..|.:.|:. ..||:..|::.:..:|..|         ..|..:..|||..
Mouse   116 TSMQDSEMILTAAFHFYSEPPRWPRAREVFCKPRAK---------NASCRLLTPGLPA------- 164

  Fly   285 SFTHKDSKIDDRFPHHHRFRLHFDVKSI---PADEKLKAAELQLT---RDALSQQVVASRSSANR 343
                               |||...:|:   .|.:.|....:.||   |.....:.::|...|.|
Mouse   165 -------------------RLHLIFRSLSQNTATQGLLRGAMALTPPPRGLWQAKDISSIIKAAR 210

  Fly   344 TRYQVLVYDITRVGVR--GQREPS----YLLLDTKTVRLNSTDTVSLDVQ-----PAVD-RWLAS 396
            ...::|:......|.:  |...||    |:|:....:.::..::|::.:|     ||.| ...|:
Mouse   211 RDGELLLSAQLDTGEKDPGVPRPSSHMPYILVYANDLAISEPNSVAVSLQRYDPFPAGDFEPGAA 275

  Fly   397 PQRNYGLLVEVRTVRSL--------------KPAPHHHVRLRRSADEAHERWQHKQPLLFTYTDD 447
            |  |......||....:              :|||..|.:    ....||.|......|
Mouse   276 P--NSSADPRVRRAAQVSKPLQDNELPGLDERPAPALHAQ----NFHKHEFWSSPFRAL------ 328

  Fly   448 GRHKARSIRDVSGGEGGGKGGRNKR-----------------QPRRPTRRKNHDD--TCRRHSLY 493
               |.|:          |:..|.|:                 :..:..||:..|:  .|.|..|.
Mouse   329 ---KPRT----------GRKDRKKKDQDTFTAASSQVLDFDEKTMQKARRRQWDEPRVCSRRYLK 380

  Fly   494 VDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMN--PGKVPKACCVPT 556
            |||:|:||::||::|..:|||||.|.|.||:......:|||.:|::|..:.  || :|:.||||.
Mouse   381 VDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIVPG-IPEPCCVPD 444

  Fly   557 QLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR 588
            :::|:.:|:|::....|||.|..|:|..|.||
Mouse   445 KMNSLGVLFLDENRNAVLKVYPNMSVETCACR 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	49/251 (20%)
dpp	NP_477311.1	TGFB	487..588	CDD:214556	43/102 (42%)
Gdf10	NP_665684.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..63
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..301		6/34 (18%)
		TGF_beta	372..475	CDD:278448	43/103 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810