Protein Alignment dpp and Gdf2

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_062379.3
• Gene: Gdf2 / 12165
• MGIID: 1321394
• Length: 428
• Species: Mus musculus
• Alignment Length: 410
• Identity: 122/410 - (29%)
• Similarity: 185/410 - (45%)
• Gaps: 83/410 - (20%)

  Fly   223 LVEIEKSLLSLFNMKRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFT 287
            |..::...|...|:...|..|:::...|:.|..||..   :..|..:.|       ::|.||||:
Mouse    58 LENMKVDFLRSLNLSGIPSQDKTRAEPPQYMIDLYNR---YTTDKSSTP-------ASNIVRSFS 112

  Fly   288 HKD---SKIDDRFPHHHRFRLH---FDVKSIPADEKLKAAELQLTRDALSQQVVASRSSANRT-- 344
            .:|   :...:.||    |:.|   |:: |||..|::..|||:|        .|:.::..:.|
Mouse   113 VEDAISTAATEDFP----FQKHILIFNI-SIPRHEQITRAELRL--------YVSCQNDVDSTHG 164

  Fly   345 -RYQVLVYDITRVG-VRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEV 407
             ...::|||:.... ...|...:...|.::.:|....:|  |:|..||.||:.:........:||
Mouse   165 LEGSMVVYDVLEDSETWDQATGTKTFLVSQDIRDEGWET--LEVSSAVKRWVRADSTTNKNKLEV 227

  Fly   408 RTVRSLKPAPHHHVRLRRSAD--------------------------------EAHERWQHKQPL 440
             ||:|       |   |.|.|                                |..|...|:|..
Mouse   228 -TVQS-------H---RESCDTLDISVPPGSKNLPFFVVFSNDRSNGTKETRLELKEMIGHEQET 281

  Fly   441 LFTYTDDGRHK-ARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHDDTCRRHSLYVDFSDVGWDDW 504
            :...|....:: |...::..|.:|....|....:.:|.|...:|   |::.||.|:|.|:|||.|
Mouse   282 MLVKTAKNAYQVAGESQEEEGLDGYTAVGPLLARRKRSTGASSH---CQKTSLRVNFEDIGWDSW 343

  Fly   505 IVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQ 569
            |:||..||||.|.|.|.|||||....|.||:|||||:...|.||.|||||||:|..:::||.:|.
Mouse   344 IIAPKEYDAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISILYKDDM 408

  Fly   570 STVVLK-NYQEMTVVGCGCR 588
            ....|| :|:.|:|..||||
Mouse   409 GVPTLKYHYEGMSVAECGCR 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	57/260 (22%)
		TGFB	487..588	CDD:214556	54/101 (53%)
Gdf2	NP_062379.3	TGFb_propeptide	75..256	CDD:279078	51/216 (24%)
		TGF_beta	325..427	CDD:278448	54/104 (52%)
		Interaction with ENG. /evidence=ECO:0000250|UniProtKB:Q9UK05	401..415		4/13 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810