Protein Alignment dpp and Bmp4

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_001303289.1
• Gene: Bmp4 / 12159
• MGIID: 88180
• Length: 408
• Species: Mus musculus
• Alignment Length: 412
• Identity: 165/412 - (40%)
• Similarity: 229/412 - (55%)
• Gaps: 43/412 - (10%)

  Fly   190 VPANAKAIIAE-QGPSTYSKEALIKDKLKPDPSTLVEIEKSLLSLFNMKRPPKIDRSKIIIPEPM 253
            :|...|..:|| ||.:...:.....:.|:       :.|.:||.:|.::|.|:..:| .:||:.|
Mouse    27 IPETGKKKVAEIQGHAGGRRSGQSHELLR-------DFEATLLQMFGLRRRPQPSKS-AVIPDYM 83

  Fly   254 KKLYAEIMGHELD-----SVNIPKPGLLTKSANTVRSFTHKDSKIDDRFP---HHHRFRLHFDVK 310
            :.||....|.|.:     ...:..|......|||||||.|::..  :..|   ....||..|::.
Mouse    84 RDLYRLQSGEEEEEEQSQGTGLEYPERPASRANTVRSFHHEEHL--ENIPGTSESSAFRFLFNLS 146

  Fly   311 SIPADEKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGVRGQREPSYL---LLDTK 372
            |||.:|.:.:|||:|.|:.:.|     .....:..:::.:|::.:  ...:..|.:|   ||||:
Mouse   147 SIPENEVISSAELRLFREQVDQ-----GPDWEQGFHRINIYEVMK--PPAEMVPGHLITRLLDTR 204

  Fly   373 TVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADEAHERWQHK 437
            .|..|.|...:.||.|||.||....|.||||.:||..:...:.....|||:.||..:....|...
Mouse   205 LVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGDWAQL 269

  Fly   438 QPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPR-RPTRRKNHDDTCRRHSLYVDFSDVGW 501
            :|||.|:..|||....:.|            |.||.|: .|.|.:..:..|||||||||||||||
Mouse   270 RPLLVTFGHDGRGHTLTRR------------RAKRSPKHHPQRSRKKNKNCRRHSLYVDFSDVGW 322

  Fly   502 DDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYL 566
            :||||||.||.|:||||.||||||||.||||||:||||||::| ..:||||||||:|.:::||||
Mouse   323 NDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISMLYL 386

  Fly   567 NDQSTVVLKNYQEMTVVGCGCR 588
            ::...|||||||||.|.|||||
Mouse   387 DEYDKVVLKNYQEMVVEGCGCR 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	70/229 (31%)
		TGFB	487..588	CDD:214556	75/100 (75%)
Bmp4	NP_001303289.1	TGFb_propeptide	41..276	CDD:279078	71/251 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..111		3/19 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..307		8/37 (22%)
		TGFB	308..408	CDD:214556	75/100 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3592
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2913
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002405
OrthoInspector	1	1.000	-	-		otm42857
orthoMCL	1	0.900	-	-		OOG6_105711
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3241
SonicParanoid	1	1.000	-	-		X157
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.890