Protein Alignment dpp and LEFTY1

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_066277.1
• Gene: LEFTY1 / 10637
• HGNCID: 6552
• Length: 366
• Species: Homo sapiens
• Alignment Length: 407
• Identity: 90/407 - (22%)
• Similarity: 143/407 - (35%)
• Gaps: 131/407 - (32%)

  Fly   229 SLLSLFNMKRPPKIDRS---KIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFTHKD 290
            |||....:|..|.:||:   :::||..::..|.               .||.:|        |.|
Human    30 SLLRQLQLKEVPTLDRADMEELVIPTHVRAQYV---------------ALLQRS--------HGD 71

  Fly   291 SKIDDRFPHHHR-------------FRLHFDVKS-IPADEKLKAAELQLTRDALSQQVV--ASRS 339
            .....||....|             ..|.|.::. :|.:.:|..|.|:|.::.:.:..:  ..|.
Human    72 RSRGKRFSQSFREVAGRFLALEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRL 136

  Fly   340 SANRTRYQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLL 404
            |....|.:|.| :..||...|....|  |:|::.|.::.:...:.||..||:.|....:....||
Human   137 SPRSARARVTV-EWLRVRDDGSNRTS--LIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLL 198

  Fly   405 VEVRTVRSLKPAPHHHVRLRRSADEAHERWQHKQPLLFTYTDDGRHKARSIRDVSGG-------- 461
            ::|...|                       :|..||.     .|.||.  :|..|.|
Human   199 LQVSVQR-----------------------EHLGPLA-----SGAHKL--VRFASQGAPAGLGEP 233

  Fly   462 -------EGGGKGGRNKRQPRRP----TRRKNHDDTCRRHSLYVDFSDVGW-DDWIVAPLGYDAY 514
                   :.|..|.:....|..|    ||       |.|..:|:|...:.| ::|::.|.|:.||
Human   234 QLELHTLDLGDYGAQGDCDPEAPMTEGTR-------CCRQEMYIDLQGMKWAENWVLEPPGFLAY 291

  Fly   515 YCHGKC---PFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQ------S 570
            .|.|.|   |..||..:                |...|:. |:.::.||:.|:....:      .
Human   292 ECVGTCRQPPEALAFKW----------------PFLGPRQ-CIASETDSLPMIVSIKEGGRTRPQ 339

  Fly   571 TVVLKNYQEMTVVGCGC 587
            .|.|.|   |.|..|.|
Human   340 VVSLPN---MRVQKCSC 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	49/233 (21%)
		TGFB	487..588	CDD:214556	29/111 (26%)
LEFTY1	NP_066277.1	TGFb_propeptide	<106..214	CDD:307025	29/138 (21%)
		TGF_beta	263..353	CDD:306518	28/109 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810