Protein Alignment dpp and GDF11

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_005802.1
• Gene: GDF11 / 10220
• HGNCID: 4216
• Length: 407
• Species: Homo sapiens
• Alignment Length: 427
• Identity: 99/427 - (23%)
• Similarity: 155/427 - (36%)
• Gaps: 85/427 - (19%)

  Fly   192 ANAKAIIAEQGPSTYSKEALIKDKLKPDPS--------------TLVEIEKSLLSLFNMKRPPKI 242
            |.|.|..|..|....|:.|   ..:.|:|.              .|..|:..:||...:|..|.|
Human    34 AAAAAAAAGVGGERSSRPA---PSVAPEPDGCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNI 95

  Fly   243 DRS--KIIIPE--PMKKL--YAEIMGHELDSVNIPKPGLLTKSANTVRSFTHK-DSKID-DRFPH 299
            .|.  |.::|:  |::::  ..:..|..|...:..:......:..||.|...: |..:. |..|.
Human    96 SREVVKQLLPKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPL 160

  Fly   300 HHRFRLHFDVKSIPADEKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGVRGQREP 364
            ...|  ||..| :...:.|||......|.......|..:.    .|.:.|..:.|..|..|.|.
Human   161 CCHF--HFSPK-VMFTKVLKAQLWVYLRPVPRPATVYLQI----LRLKPLTGEGTAGGGGGGRR- 217

  Fly   365 SYLLLDTKTVRLNSTD--TVSLDVQPAVDRWLASPQRNYGLLVEV-------RTVRSLKPAPHHH 420
             ::.:.:..:.|:|..  ..|:|.:..:..|...||.|:|:.:..       ..|.||.|..
Human   218 -HIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGA--- 278

  Fly   421 VRLRRSADEAHERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHDD 485
                                      :|.|....:|.:...:      |::|.........:.:.
Human   279 --------------------------EGLHPFMELRVLENTK------RSRRNLGLDCDEHSSES 311

  Fly   486 TCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPK 550
            .|.|:.|.|||...|| |||:||..|.|.||.|:|.:.....:..|:      ||...||.....
Human   312 RCCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQANPRGSAG 369

  Fly   551 ACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGC 587
            .||.||::..:.|||.||:..::......|.|..|||
Human   370 PCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	46/235 (20%)
		TGFB	487..588	CDD:214556	38/101 (38%)
GDF11	NP_005802.1	TGFb_propeptide	61..285	CDD:366248	49/261 (19%)
		TGF_beta_GDF8	301..407	CDD:381658	38/113 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810