Protein Alignment dpp and nodal3.4

DIOPT Version :10

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_001297040.1
• Gene: nodal3.4 / 101732995
• XenbaseID: XB-GENE-29086643
• Length: 401
• Species: Xenopus tropicalis
• Alignment Length: 442
• Identity: 101/442 - (22%)
• Similarity: 171/442 - (38%)
• Gaps: 130/442 - (29%)

  Fly   229 SLLSLF--------NMKRPPKIDRSKII----------------------IPEPMKKLYAEIMG- 262
            :.||||        .|..||.:...|.|                      .|..|.:||..|:.
 Frog     2 AFLSLFLCLVFSSPLMAMPPALQGRKAISPASILKGPSTDNGARDFHGRKFPHFMMQLYQNIISR 66

  Fly   263 HELDSVNIPKPGLLTKSANTVRSFTHKDSKIDDRFPHHHRFRLHFDVKSIPADEKLKAAELQL-- 325
            .:.|..|:..|.|  :.::||:||..|......     :.:.|.||:.||....:||.|||::
 Frog    67 RDKDLSNLEHPTL--QESDTVQSFIAKSYTTVG-----NHWTLFFDMSSISTSNELKLAELRICL 124

  Fly   326 ---------------TRDALSQQVVASRSS--ANRTRYQVLVYDITRVGVRGQREPSYLLLDTKT 373
                           |:|...:..:.|..:  ::.......|:::|.|      ..:||:...:.
 Frog   125 PSFGKSHSVTVEIYHTKDTKEKLFMGSFKTKISSALDADCKVFNLTMV------LHNYLIRGKRL 183

  Fly   374 VRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVE----------VRTVRSLKPAPHHHVRLRRSAD 428
            ::               |.::.:.    |||:.          ...|.:||...:|   :...|.
 Frog   184 IK---------------DEYIQAK----GLLLRDLEKSAAEKGAENVDTLKQDKYH---VSDFAA 226

  Fly   429 E-------AHERWQHKQ----------PLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRR 476
            |       |.||.|.|.          ||.:...|:. :|....|.:.         |||::..|
 Frog   227 ERIILVVFAKERSQAKPDPPSLGKQLFPLKYGMADNA-NKVNGFRRLR---------RNKKEKTR 281

  Fly   477 -------PTRRKNHDDTCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHA 534
                   |...:.....||:..::|||..:||..|||.|..|:||.|...|..||.:..::||::
 Frog   282 IDVGTTPPKPVEEIKPKCRKVDMFVDFQKIGWGSWIVYPKAYNAYRCESACAVPLNETDDATNYS 346

  Fly   535 VVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCG 586
            .:::|:...:..:.....|||.::.|::|||..::. .||::::||.|..||
 Frog   347 YIKSLLPLSDTERRECPSCVPVKMRSMSMLYYENED-FVLRHHEEMIVEECG 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:480997	58/291 (20%)
		TGF_beta_DPP	480..588	CDD:381662	35/107 (33%)
nodal3.4	NP_001297040.1	TGFb_propeptide	53..>139	CDD:480997	24/92 (26%)
		TGF_beta_SF	299..397	CDD:477357	33/98 (34%)