DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpp and wdr88

DIOPT Version :9

Sequence 1:	NP_477311.1	Gene:	dpp / 33432	FlyBaseID:	FBgn0000490	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	XP_004913613.1	Gene:	wdr88 / 101732918	XenbaseID:	XB-GENE-6044415	Length:	397	Species:	Xenopus tropicalis

Alignment Length:	152	Identity:	36/152 - (23%)
Similarity:	58/152 - (38%)	Gaps:	38/152 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 QRSHHKKSHHHRSHQPKQASASTESHQSSSIES-----------IFVEEPTLVL---DREVASIN 189
            |..|.:....|::|: ...|:.|.|...|.|.|           :......|||   :..|..::
Frog   246 QFRHQRPDVLHKAHK-GSVSSCTFSKDMSVIVSGGYDKTVVLWDVIAASKKLVLKGHEDWVLDVS 309

  Fly   190 VPANAKAIIAEQGPST--------YSKEALIKDKLKPDPSTLVEIE--KSLLSLFNMKRPPKIDR 244
            :.||.|.|::....||        |.|...:.:.::...||:|:.|  |...|..|...|..:.|
Frog   310 LSANKKWIVSSSKDSTLRLWNIENYEKIPAVTENIRALGSTVVQCEECKKPFSFMNWDNPDLLKR 374

  Fly   245 ---------SKII----IPEPM 253
                     |:|.    ||:|:
Frog   375 CVFCRLATPSRICPLPPIPDPV 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	11/44 (25%)
dpp	NP_477311.1	TGFB	487..588	CDD:214556
wdr88	XP_004913613.1	WD40	34..330	CDD:238121	20/84 (24%)
		WD40 repeat	47..83	CDD:293791
		WD40 repeat	89..127	CDD:293791
		WD40 repeat	129..166	CDD:293791
		WD40 repeat	174..209	CDD:293791
		WD40 repeat	216..254	CDD:293791	2/7 (29%)
		WD40 repeat	263..289	CDD:293791	6/25 (24%)
		WD40 repeat	305..329	CDD:293791	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900