Protein Alignment dpp and nodal

DIOPT Version :10

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: XP_002936396.2
• Gene: nodal / 100497218
• XenbaseID: XB-GENE-483209
• Length: 398
• Species: Xenopus tropicalis
• Alignment Length: 408
• Identity: 105/408 - (25%)
• Similarity: 173/408 - (42%)
• Gaps: 80/408 - (19%)

  Fly   229 SLLSLFNMKRPPKIDRSKII---------IPEPMKKLYAEI----MGHELDSVNIPKPGLLTKSA 280
            |.|...:.|....::|:|.:         :|..|..||...    :.|.:::.  |.|....:|
 Frog    23 SYLKHMSSKPQDHVNRTKAVGSKDFAALPLPSYMLNLYQSFHHSELSHGMEAA--PSPPSNHRS- 84

  Fly   281 NTVRSFTHKDSKIDDRFPH-HHRFRLHFDVKSIPADEKLKAAELQLTRDALSQQVVASRSSANRT 344
            :.:||...|.      |.| ...:.|.||..|:..||:.:.||::.........:||.
 Frog    85 DIIRSLAAKS------FDHGGSLWTLVFDFSSLSQDEEHQFAEVRFDFRVFDGAIVAG------- 136

  Fly   345 RYQVLVYDITRVGVRGQREPSYLLLD--TKTVRLNSTDT-VSLDVQPAVDRWLASPQRNYGLLVE 406
             .:|:|....:.....:...|||.:.  |.|:|..|::| |.|:....:.:|....::.
 Frog   137 -MEVMVDFFHQSSTCQKNSQSYLYVGSITGTLRSRSSETWVMLEATDIIHKWFEKDEKG------ 194

  Fly   407 VRTVRSLKPAPHHHV----RLRRSADEAHERWQH-----KQPLLFTYTDDGRHK-----ARSIRD 457
                   |.....||    :|.| |..|..|:|.     :|.|:..|::..:.:     |..::|
 Frog   195 -------KNNSEAHVKQLEKLAR-AKSAERRYQQQNTEDRQILMMVYSNISKKERLSGTATLLQD 251

  Fly   458 VSGGE-----GGGKGGRNKRQPRRPTRRKNH------------DDTCRRHSLYVDFSDVGWDDWI 505
            .:..:     .|.:...|.|:.||....|.|            ...|||...:|||..:|||.||
 Frog   252 AAHSKYLTVMPGIQTISNSRRHRRSHIFKEHMGMKHVPTAGSSRTLCRRVDFFVDFKQIGWDSWI 316

  Fly   506 VAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQS 570
            :.|..|:||.|.|:||.|:.:.....|||.:|:|:|....||.|:.||||.::.|::|:|. |..
 Frog   317 IHPQKYNAYRCEGECPSPVNESVKPNNHAYMQSLLNYYAKGKAPEVCCVPIRMSSLSMVYY-DHD 380

  Fly   571 TVVLKNYQEMTVVGCGCR 588
            .:..:|::.|.|..|||:
 Frog   381 DIAFQNHEGMIVEECGCQ 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:480997	52/240 (22%)
		TGF_beta_DPP	480..588	CDD:381662	44/119 (37%)
nodal	XP_002936396.2	TGF_beta_NODAL	296..398	CDD:381637	42/102 (41%)