DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpp and bmp8

DIOPT Version :9

Sequence 1:	NP_477311.1	Gene:	dpp / 33432	FlyBaseID:	FBgn0000490	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	XP_002941697.3	Gene:	bmp8 / 100494880	XenbaseID:	XB-GENE-485424	Length:	425	Species:	Xenopus tropicalis

Alignment Length:	462	Identity:	135/462 - (29%)
Similarity:	209/462 - (45%)	Gaps:	87/462 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 FVEEPTLVLDREVASINVPANAKAIIAEQGPSTYSKEAL----IKDKLKPDPSTLVEIEKSLLSL 233
            |..|.:.||...:|::::    .||:.:....::.|..|    |:.||......  |:::.:||:
Frog     3 FSREMSHVLQMTLAAMSI----LAILWDLTSGSFVKNHLHSSFIQRKLSGREKR--EMQREILSI 61

  Fly   234 FNMK-RPPKIDRSKIIIPEP--MKKLYAEIMGHELD--------------SVNIPKPGLLTKSAN 281
            ..:. ||.......:....|  |..||..:...|.:              |...|..|.:...|:
Frog    62 MGLPGRPRPASGGHVPSSAPLFMLDLYHAMCSEEDEDGMPGVSRAHFTTLSTQSPPLGTVISEAD 126

  Fly   282 TVRSFTH---KDSKIDDRFPHHHRFRLHFDVKSIPADEKLKAAELQLTRDALSQQVVASRS---S 340
            ||.||.:   .|..|..:.|:...|:  ||:..||..|.:..||.:|.:         .||   :
Frog   127 TVMSFVNMVEHDRDIFQQKPYWKEFK--FDMTQIPTGESVTVAEFRLFK---------MRSFLRN 180

  Fly   341 ANRTRYQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLV 405
            .|||.: :.:::|.:  .||.|||...|||.::........:..||..|.:.||.:.:.|.|:.:
Frog   181 LNRTLH-ISLFEIKK--ERGHREPELTLLDHESTLAGDEGWLVFDVTAASNHWLLNSKNNLGIRL 242

  Fly   406 EVRTVRSLKPAPHHHVRLRRSADEAHERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRN 470
            .|.|.:.....|.....|.|.|..:      |||.:.|:....|::.||.|.|
Frog   243 YVETDQGQSIDPGIAGILGRRAPRS------KQPFMVTFFRVSRNQIRSARAV------------ 289

  Fly   471 KRQPRRPTRRKNHD--------------------DTCRRHSLYVDFSDVGWDDWIVAPLGYDAYY 515
              :..|..::|.||                    ..|:||.|||.|.|:||.||::||.||.|:|
Frog   290 --KQLRKRQQKKHDLPHPNKLPGILDHLHVTDSRQVCKRHELYVSFRDLGWLDWVIAPQGYSAFY 352

  Fly   516 CHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEM 580
            |.|:|.|||....|:||||::|:||:.|.|..||||||.||:|.:.::||.:..:.|:||.::.|
Frog   353 CEGECSFPLDSCMNATNHAILQSLVHLMKPESVPKACCAPTKLSATSVLYYDSNNNVILKKHRNM 417

  Fly   581 TVVGCGC 587
            .|..|||
Frog   418 VVKSCGC 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	60/241 (25%)
dpp	NP_477311.1	TGFB	487..588	CDD:214556	53/101 (52%)
bmp8	XP_002941697.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063560at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X157
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920