DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpp and espn

DIOPT Version :9

Sequence 1:	NP_477311.1	Gene:	dpp / 33432	FlyBaseID:	FBgn0000490	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	XP_012822811.2	Gene:	espn / 100379704	XenbaseID:	XB-GENE-960582	Length:	1343	Species:	Xenopus tropicalis

Alignment Length:	215	Identity:	47/215 - (21%)
Similarity:	76/215 - (35%)	Gaps:	73/215 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 GASTSTALAKAFN---------PFSE--PASFSDSDKSHRSKT-NKKPSKSDANRQFNEVHKPRT 112
            |..||....:|.|         |.||  |.....:|...||:. ||:||..|   .:..:.:..|
Frog   466 GQHTSEIYVQAKNNLRHVDNELPSSENSPEGLRRADSCRRSRNFNKQPSTGD---YYKYIEQSTT 527

  Fly   113 DQLENSKNKSKQLVNKPNHNKMAVKEQRSHHKKSHHHRSHQPKQASASTESHQSSSI-------- 169
               |.|.:::.|:      .|||                |..:.:..|:|:.|:.:|
Frog   528 ---EKSTSETSQV------KKMA----------------HSEEGSVKSSETVQNGNISGNVPPPP 567

  Fly   170 ------ESIFVEEPTLVLDREVA---------SINVPANAKAIIAEQGPSTYSKEALIKDK---- 215
                  |::....|...|..|.:         |.|...:.|: .....|:..:.|.|.:.|
Frog   568 LPPPLPENLCFPPPPPPLPTESSIICSSSQRRSSNSTGSTKS-FNMMSPTGDNSELLAEIKAGKS 631

  Fly   216 LKPDPSTLVEIEKSLLSLFN 235
            |||.|.:     |.|.::|:
Frog   632 LKPTPQS-----KGLTTVFS 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	3/11 (27%)
dpp	NP_477311.1	TGFB	487..588	CDD:214556
espn	XP_012822811.2	Ank_2	6..101	CDD:403870
		ANK repeat	6..33	CDD:293786
		ANK repeat	35..67	CDD:293786
		ANK repeat	69..101	CDD:293786
		ANK repeat	103..127	CDD:293786
		Ank_2	108..202	CDD:403870
		ANK repeat	138..169	CDD:293786
		ANK repeat	171..203	CDD:293786
		Ank_2	176..270	CDD:403870
		ANK repeat	205..269	CDD:293786
		Ank_2	244..324	CDD:403870
		ANK repeat	271..302	CDD:293786
		WH2	615..640	CDD:396675	8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900