Protein Alignment dpp and gdf5

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_001128589.1
• Gene: gdf5 / 100189547
• XenbaseID: XB-GENE-481784
• Length: 496
• Species: Xenopus tropicalis
• Alignment Length: 537
• Identity: 156/537 - (29%)
• Similarity: 234/537 - (43%)
• Gaps: 88/537 - (16%)

  Fly    77 PASFSDSDKSH-RSKTNKKPSKSDANRQFNEVHKPRTDQLENSKNKSKQLVNKPNHNKMAVKEQR 140
            |.....|::|| .:|.....:.........:|:..||..|.:.....|.....|.........:.
 Frog    23 PLVLGHSEQSHPGTKVGIAGTGGKERNPLPKVNATRTGILGHGVGLQKGRSKVPLVQSRIFLSKN 87

  Fly   141 SHHKKSHHHRSHQPKQASASTESHQSSSIESIFVEEPTLVLDREVASINVPANAKAIIAEQGPST 205
            ...||....|:: |...:.:.|:.||.  |.|....|..|..:        |:.|.|      :.
 Frog    88 EDIKKQAASRAN-PHVKTGNAENRQSG--EKIETPRPPHVTSK--------ASTKLI------NI 135

  Fly   206 YSKEALIKDKLKPDPSTLVEIEKSLLSLFNMKRPPKIDRSKIIIP-EPMKKLYAEIMGHELDSVN 269
            ::..|..|.|..|:|.|    ||.....|  |.|       :|.| |.|..||..:...|...:|
 Frog   136 HADSAGFKPKRPPNPLT----EKEQKDAF--KHP-------LITPHEYMLSLYRTLSDVERKGIN 187

  Fly   270 IP---KPGLLTKSANTVRSFTHKDSKIDDRFPHHHRFRLHFDVKSIPADEKLKAAELQLTRDALS 331
            ..   :.||    |||:.||..|..  |:|.....|.:..||:.::..| .|..|||::.|   .
 Frog   188 GSLKLEAGL----ANTITSFIDKGQ--DERMAAARRQKYTFDISALEKD-GLLGAELRILR---K 242

  Fly   332 QQVVASRSSANRTRYQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRW--L 394
            :.:.|..:||.:. :|:.:|...      ..:.|..|||::.  |.|.||...:|   .|.|  .
 Frog   243 RPIDAKLNSAGKL-WQIKLYSCP------ANKKSATLLDSRP--LGSIDTPKWEV---FDIWKLY 295

  Fly   395 ASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADEAHERWQHKQPLLFTYTDDGRHKARSIRDVS 459
            .:.:.:..|..|:..:...|||....|...|:..:.:|:     .:...:   ||.|.   ||:.
 Frog   296 KNFKNSVQLCFELEVLDKGKPADLRSVGFNRTGRQTNEK-----AIFLVF---GRTKK---RDLF 349

  Fly   460 GGEGGGKGGR----------NKRQPRR---PTRR-----KNHDDTCRRHSLYVDFSDVGWDDWIV 506
            ..|...:.|:          |:|:.||   .||:     ||....|.:..|:|:|.|:||||||:
 Frog   350 FNEIKARSGQDDKTVYEYLFNQRRKRRAPLSTRQGKRPNKNSKARCSKKPLHVNFKDMGWDDWII 414

  Fly   507 APLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQST 571
            |||.|:||:|.|.|.|||..|...|||||:|||:|:|:|...|..|||||:|..:::||.:..:.
 Frog   415 APLEYEAYHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPETTPPTCCVPTRLSPISILYTDSANN 479

  Fly   572 VVLKNYQEMTVVGCGCR 588
            ||.|.|::|.|..||||
 Frog   480 VVYKQYEDMVVESCGCR 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	56/224 (25%)
		TGFB	487..588	CDD:214556	52/100 (52%)
gdf5	NP_001128589.1	TGFb_propeptide	142..328	CDD:279078	60/220 (27%)
		TGFB	395..496	CDD:214556	52/100 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910