DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9886 and Glyctk

DIOPT Version :9

Sequence 1:	NP_001259941.1	Gene:	CG9886 / 33431	FlyBaseID:	FBgn0031428	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001102919.1	Gene:	Glyctk / 684314	RGDID:	1591498	Length:	523	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	205/522 - (39%)
Similarity:	280/522 - (53%)	Gaps:	82/522 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EQMRQIFVQAVNAVHPEKVFADFQKFDLRPQIGENATDISIKLNGERQDISGKT------CHIVG 66
            ||.||:|..||.||.|            .|.:...   :|:..:|::..:..:|      .::||
  Rat    36 EQARQLFDSAVGAVQP------------GPMLQRT---LSLDPSGKQLKVRDRTFQLQENLYLVG 85

  Fly    67 FGKAVLGMANKVQQDLGATSAGGVLSVP------VNTLKQFQQPVAP--GLVVHEGAANNLPDEN 123
            |||||||||....:.||.....||:|||      |....:.:..:.|  .:.|.|||.:||||.:
  Rat    86 FGKAVLGMAAAADELLGQHLVQGVISVPKGIRAAVELAGKQEMLLKPHSHIQVFEGAEDNLPDRD 150

  Fly   124 ALKAAREIKQLAEKMTAQDILFVFISGGGSALLPLPRSPLTLEDKRSIADKLMKRGASIQEINAV 188
            ||:||:.|:||||::||.|:|.|.||||||||||.|..|:|||:|:::...|..|||:|||:|.:
  Rat   151 ALRAAQAIQQLAERLTADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTKLLAARGATIQELNTI 215

  Fly   189 RIACSDIKGGRLARLAGQAGLLVTFVLSDIIGDPLELIACGPTIQPEAAASPSD---ILKKHHVW 250
            |.|.|.:|||.||:.|..| .:|:.:|||:||||||:||.|||:  .:..|..|   ||..:.:.
  Rat   216 RKALSQLKGGGLAQAAYPA-QVVSLILSDVIGDPLEVIASGPTV--ASTHSVQDCLHILNHYGLR 277

  Fly   251 EELSPEIRRVFEQPEEQKNTSLPE---HKV-FVVGSNVIATSTAAHEAERLGYIPCVLSCAVQGD 311
            ..|...::.|..:.:...:.  |.   |.: .::|||.:|.:.|..:||.|||...|||.|:|||
  Rat   278 AALPRSVKTVLSRADSDPHG--PHTCGHVLNVIIGSNSLALAEAQRQAEVLGYHAMVLSTAMQGD 340

  Fly   312 VAQVAGDY----------------QRLLHGIQEAKQHGIL------DPQLREKYAFGERSYPTFR 354
            |.:||..|                :|.|.  :|||.|.:.      |.||.|
  Rat   341 VRRVAQFYGLLARVAAACLTSSTAERPLE--EEAKLHQLAAELQLPDLQLEE------------- 390

  Fly   355 RALEDHMSSKKPLFLICGGEPVIKVSGHGLGGRSQHLALLMSQALHRDE-AMRDCTFLSAGTDGI 418
             |||....:|.|:.|:.||||.:::.|.|.|||:|.|||.:...|.:.. ...|..|||.||||.
  Rat   391 -ALEAVAKAKGPVCLLAGGEPTVQLQGSGKGGRNQELALRVGAELGKQPLGPVDVLFLSGGTDGQ 454

  Fly   419 DGPTDAAGAFGDSSVVESYLGDHTLDELAETLRNCDSYNFYKNLAQGEHHVLTGHTGTNVMDLHF 483
            ||||..|||:..|.:| |......|| .|..|.|.|||.|:.:...|.|.:.||.|||||||:|.
  Rat   455 DGPTKVAGAWVMSDLV-SQASAENLD-FATFLDNNDSYTFFCSFQGGTHLLHTGLTGTNVMDVHL 517

  Fly   484 LV 485
            ||
  Rat   518 LV 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9886	NP_001259941.1	DUF4147	10..261	CDD:290386	108/267 (40%)
		GckA	12..487	CDD:225254	202/518 (39%)
		MOFRL	367..480	CDD:282951	51/113 (45%)
Glyctk	NP_001102919.1	GckA	38..515	CDD:225254	199/514 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350346
Domainoid	1	1.000	163	1.000	Domainoid score	I3888
eggNOG	1	0.900	-	-		E1_COG2379
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14738
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2889
OMA	1	1.010	-	-		QHG60856
OrthoDB	1	1.010	-	-		D1371490at2759
OrthoFinder	1	1.000	-	-		FOG0006220
OrthoInspector	1	1.000	-	-		oto97320
orthoMCL	1	0.900	-	-		OOG6_105004
Panther	1	1.100	-	-	LDO	PTHR12227
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5161
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810