DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9886 and Glyctk

DIOPT Version :9

Sequence 1:	NP_001259941.1	Gene:	CG9886 / 33431	FlyBaseID:	FBgn0031428	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001034675.1	Gene:	Glyctk / 235582	MGIID:	2444085	Length:	523	Species:	Mus musculus

Alignment Length:	517	Identity:	201/517 - (38%)
Similarity:	277/517 - (53%)	Gaps:	70/517 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EQMRQIFVQAVNAVHPEKVFADFQKFDLRPQIGENATDISIKLNGERQDISGKT------CHIVG 66
            ||.||:|..||.||.|            .|.:...   :|:..:|.:..:..:|      .::||
Mouse    36 EQARQLFDSAVGAVQP------------GPMLQRT---LSLDPSGRQLKVRDRTFQLRENLYLVG 85

  Fly    67 FGKAVLGMANKVQQDLGATSAGGVLSVPVN-------------TLKQFQQPVAPGLVVHEGAANN 118
            |||||||||...::.|......||:|||..             .||...:     :.|.|||.:|
Mouse    86 FGKAVLGMAAAAEELLAQHLVQGVISVPKGIRAAMEHAGKKEMLLKPHSR-----IQVFEGAEDN 145

  Fly   119 LPDENALKAAREIKQLAEKMTAQDILFVFISGGGSALLPLPRSPLTLEDKRSIADKLMKRGASIQ 183
            |||.:||:||..|:||||.:||.|:|.|.||||||||||.|..|:|||:|:.:...|..|||:||
Mouse   146 LPDRDALRAALTIQQLAEGLTADDLLLVLISGGGSALLPAPIPPVTLEEKQMLTKLLAARGATIQ 210

  Fly   184 EINAVRIACSDIKGGRLARLAGQAGLLVTFVLSDIIGDPLELIACGPTIQPEAAASPSD---ILK 245
            |:|.:|.|.|.:|||.||:.|..| .:::.:|||:||||||:||.|||:  .:..|..|   ||.
Mouse   211 ELNTIRKALSQLKGGGLAQAAYPA-QVISLILSDVIGDPLEVIASGPTV--ASTHSVQDCLHILN 272

  Fly   246 KHHVWEELSPEIRRVFEQPEEQKNTSLPE---HKV-FVVGSNVIATSTAAHEAERLGYIPCVLSC 306
            .:.:...|...::.|..:.:...:.  |.   |.: .::|||.:|.:.|..:||.|||...|||.
Mouse   273 HYGLRAALPRSVKTVLSRADSDPHG--PHTCGHVLNVIIGSNSLALAEAQRQAEVLGYHAMVLST 335

  Fly   307 AVQGDVAQVAGDYQRLLHGIQEAKQHGILDPQLREK---------YAFGERSYPTFR--RALEDH 360
            |:||||.:||..|..|   .:.|..|  |.|.|.|:         ....|...|..:  .|||..
Mouse   336 AMQGDVKRVARFYGLL---ARVAAAH--LTPSLAERPLEEEAELHQLAAELQLPDLQLEEALEAV 395

  Fly   361 MSSKKPLFLICGGEPVIKVSGHGLGGRSQHLALLMSQALHRDE-AMRDCTFLSAGTDGIDGPTDA 424
            :.:|.|:.|:.||||.:::.|.|.|||:|.|||.:...|.|.. ...|..|||.||||.||||..
Mouse   396 VKAKGPVCLLAGGEPTVQLQGSGKGGRNQELALHVGVELGRQPLGPIDVLFLSGGTDGQDGPTKV 460

  Fly   425 AGAFGDSSVVESYLGDHTLDELAETLRNCDSYNFYKNLAQGEHHVLTGHTGTNVMDLHFLVV 486
            |||:..|.:: |.....:|| :|.:|.|.|||.|:.....|.|.:.||.|||||||:|.|::
Mouse   461 AGAWVMSDLI-SQASAESLD-IATSLANNDSYTFFCRFRGGTHLLHTGLTGTNVMDVHLLIL 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9886	NP_001259941.1	DUF4147	10..261	CDD:290386	106/272 (39%)
		GckA	12..487	CDD:225254	198/513 (39%)
		MOFRL	367..480	CDD:282951	51/113 (45%)
Glyctk	NP_001034675.1	GckA	38..515	CDD:225254	196/508 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846816
Domainoid	1	1.000	156	1.000	Domainoid score	I4204
eggNOG	1	0.900	-	-		E1_COG2379
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14738
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2988
Isobase	1	0.950	-	0	Normalized mean entropy	S5160
OMA	1	1.010	-	-		QHG60856
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006220
OrthoInspector	1	1.000	-	-		oto93778
orthoMCL	1	0.900	-	-		OOG6_105004
Panther	1	1.100	-	-	LDO	PTHR12227
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2937
SonicParanoid	1	1.000	-	-		X5161
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740