DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and Slc17a6

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_445879.1	Gene:	Slc17a6 / 84487	RGDID:	620531	Length:	582	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	259/553 - (46%)
Similarity:	346/553 - (62%)	Gaps:	37/553 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 GDREGRGPGGGHAYDDDDDRPDSPASFEEIE-RPPLRKIDK---YCKAECPCMPARYTIATMACV 104
            |.:...|...|..|...:.:.|:..:.|..| ..||...:|   .|...|..:|.||.||.|:.:
  Rat    15 GIKNFAGKSLGQIYRVLEKKQDNRETIELTEDGKPLEVPEKKAPLCDCTCFGLPRRYIIAIMSGL 79

  Fly   105 GFMIAFGMRCNMSAAKLKGEHNGTVF-----------MNWTVAVESHVDSSFFWGYLVTQIPGGF 158
            ||.|:||:|||:..|.:...:|.|:.           .||.......:..||||||::||||||:
  Rat    80 GFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGY 144

  Fly   159 IASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPP 223
            |||:..||::||.:|:.::||::.:|.|..:.:| .||.||:||||.||||||||||||..||||
  Rat   145 IASRLAANRVFGAAILLTSTLNMLIPSAARVHYG-CVIFVRILQGLVEGVTYPACHGIWSKWAPP 208

  Fly   224 MERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPA 288
            :|||||||.:|.|||||.|:.:||:|:|....|:.:.||.||.||::|||||:.:.:|:|.|||.
  Rat   209 LERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPT 273

  Fly   289 ISIPELKYIEKSLGESAH--PTMPSLKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFL 351
            |:..|.:|||:|:||||:  ..|...| ||||:...||||||||||||||||.||||::.|.::.
  Rat   274 ITDEERRYIEESIGESANLLGAMEKFK-TPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYF 337

  Fly   352 KHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFNCGGFGMEGLFFLF 416
            :..|||::.:.|.:.::|||:||.|||.||.:||.||...|||||.|||:.||||||||....|.
  Rat   338 EEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLV 402

  Fly   417 VAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGL 481
            |.:|.|...|:..|...|.||||||||:|||||||||||||||||:|||:|||:|::.|..:..:
  Rat   403 VGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAM 467

  Fly   482 IQANPTGCWTTVFTLAACVHLVGCTFYGIFASGELQPWAEPPAEEQKVWAPPPGAITNTDPSQAG 546
            .:......|..||.:||.||..|..||.:|||||.||||:|  ||             |...:.|
  Rat   468 TKNKSREEWQYVFLIAALVHYGGVIFYALFASGEKQPWADP--EE-------------TSEEKCG 517

  Fly   547 MLGDYMKETSFGAPEYTEQSQMQQSTAISYGAT 579
            .:.:...:...|  :.| |:.:...|..|||||
  Rat   518 FIHEDELDEETG--DIT-QNYINYGTTKSYGAT 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	221/426 (52%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	208/386 (54%)
Slc17a6	NP_445879.1	2A0114euk	70..511	CDD:129972	235/457 (51%)
Slc17a6	NP_445879.1	MFS	75..498	CDD:119392	219/424 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342621
Domainoid	1	1.000	440	1.000	Domainoid score	I529
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121617
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1323
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D144672at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		otm46209
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	1	1.100	-	-	LDO	PTHR11662
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910