DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and slc17a5

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001072823.1	Gene:	slc17a5 / 780284	XenbaseID:	XB-GENE-853687	Length:	496	Species:	Xenopus tropicalis

Alignment Length:	498	Identity:	172/498 - (34%)
Similarity:	259/498 - (52%)	Gaps:	52/498 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DDDRPDSPASFEEIERPPLRKIDKYCKAECP------CMPARYTIATMACVGFMIAFGMRCNMSA 118
            |.|..|......|...|      ||....||      |..|||.:|.||.:||.:.:.:|.|:|.
Frog     5 DSDSGDRSPLLAEYGEP------KYSVQSCPPAKVPVCCSARYNLALMALLGFFMLYALRVNLSV 63

  Fly   119 AKLKGE-------------------------HNGT-VFMNWTVAVESHVDSSFFWGYLVTQIPGG 157
            |.:...                         ||.| ...:|....:..:..|||:||::||||||
Frog    64 ALVDMVNSTSTPRENTTANICPDHTSAPAVLHNSTGQKYDWDANTQGWILGSFFYGYILTQIPGG 128

  Fly   158 FIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAP 222
            ::|.|....::.|..|:.:|...|..|.|.....| .:|.||.|:||.||||:||.|.:|..|||
Frog   129 YVAGKIGGKQLLGFGILGTAVFTLLTPLAADFGAG-CLIAVRALEGLGEGVTFPAMHAMWARWAP 192

  Fly   223 PMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHP 287
            |:|||||.:|:::|:..|.||.||:|||:...:.:...||.:|..|::|::.|.:|..:.|:.|.
Frog   193 PLERSRLLSLSYAGAQLGTVVSLPVSGLICYYMDWIYVFYIFGTLGVLWFIMWCFLVSDTPQSHR 257

  Fly   288 AISIPELKYIEKSLGESAHPTMPSLKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLK 352
            :|:..|.:||..:|...    :...|:.|...||:|:|::|||||:|..:|.||.|:....:::|
Frog   258 SITDSEKEYILYTLQNQ----LSYRKSVPCCAMMKSLPLWAIIVAHFSYNWTFYTLLTLLPTYMK 318

  Fly   353 HKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFNCGGFGMEGLFFLFV 417
            ....|..:|.||:.:||:|.....:...|::||.||:...:||..|||:||..|.....:|.|..
Frog   319 EILRFNAQENGFLSALPYLGCWVFMIMAGVIADCLREKLNISTKVVRKIFNTLGMLGPAIFLLAA 383

  Fly   418 AHSSTATG-----AMFALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYA 477
            .:    ||     |:..||......||:::||.:|||||||.:|.:|:|::|...|:.|::.|..
Frog   384 GY----TGCNYSLAVVFLTLSTTLGGFSVAGYGINHLDIAPSFAGLLLGITNTFATIPGMVGPVI 444

  Fly   478 LDGLIQANPTGCWTTVFTLAACVHLVGCTFYGIFASGELQPWA 520
            ...|...|....|..||.:||.::..|..|:.|||||.:|.||
Frog   445 AKALTHDNTVEQWQIVFYIAAAINFFGAIFFIIFASGNVQDWA 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	152/444 (34%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	140/404 (35%)
slc17a5	NP_001072823.1	MFS_SLC17A5	43..466	CDD:340939	148/431 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000