Protein Alignment VGlut and Slc17a7

DIOPT Version :9

• Sequence 1: NP_001245848.1
• Gene: VGlut / 33427
• FlyBaseID: FBgn0031424
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_892038.2
• Gene: Slc17a7 / 72961
• MGIID: 1920211
• Length: 560
• Species: Mus musculus
• Alignment Length: 614
• Identity: 276/614 - (44%)
• Similarity: 354/614 - (57%)
• Gaps: 93/614 - (15%)

  Fly     7 FKEKATGVFGGLKPNMEKFEISQSYHGGHGGYEEMEGGDREGRGPGGGHAYDDDDDRPDSPASFE 71
            |::.|....|.|...:||.:         .|.|.:| ...:|| |...|..|
Mouse     8 FRKLAGRALGRLHRLLEKRQ---------EGAETLE-LSADGR-PVTTHTRD------------- 48

  Fly    72 EIERPPLRKIDKYCKAECPC--MPARYTIATMACVGFMIAFGMRCNMSAAKLKGEHNGTVF---- 130
                ||:        .:|.|  :|.||.||.|:.:||.|:||:|||:..|.:...:|.|..
Mouse    49 ----PPV--------VDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGH 101

  Fly   131 -------MNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMT 188
                   .||.......:..||||||:|||||||||..||.||::||.:||:::||::.:|.|..
Mouse   102 VVVQKAQFNWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAAR 166

  Fly   189 LMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLAD 253
            :.:| .||.||:||||.||||||||||||..||||:|||||||.||.|||||.||.:||:|:|..
Mouse   167 VHYG-CVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQ 230

  Fly   254 AVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGESAHPTMPSLK-TTPW 317
            ..|:.:.||.||.|||.||:||:.:.:|:|..||:||..|.||||.::||||....|..| .|||
Mouse   231 YSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMNPVTKFNTPW 295

  Fly   318 REMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGM 382
            |....||||||||||||||||.||||::.|.::.:..|||::.:.|.|.:||||:||.|||.||.
Mouse   296 RRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQ 360

  Fly   383 LADHLRKNGILSTTNVRKLFNCGGFGMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVN 447
            :||.||...|:||||||||.||||||||....|.|.:|.:...|:..|...|.||||||||:|||
Mouse   361 IADFLRSRHIMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVN 425

  Fly   448 HLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPTGCWTTVFTLAACVHLVGCTFYGIFA 512
            ||||||||||||||:|||:|||:|::.|..:..:.:......|..||.:|:.||..|..|||:||
Mouse   426 HLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFA 490

  Fly   513 SGELQPWAEPPAEEQKVWAPPPGAITNTDPSQAGMLGDYMKETSFGAPEYTEQSQMQQSTAISYG 577
            |||.||||||  ||.             ...:.|.:|......|       ::|:|:..
Mouse   491 SGEKQPWAEP--EEM-------------SEEKCGFVGHDQLAGS-------DESEMEDE------ 527

  Fly   578 ATGHVANNPFAMASGAPPIAEEDAPPTYG 606
                      |...||||.    .||:||
Mouse   528 ----------AEPPGAPPA----PPPSYG 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	228/425 (54%)
		MFS_1	101..475	CDD:284993	215/385 (56%)
Slc17a7	NP_892038.2	MFS_SLC17A6_7_8_VGluT	66..490	CDD:340940	227/424 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..560		20/88 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838688
Domainoid	1	1.000	440	1.000	Domainoid score	I548
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1363
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D144672at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		otm44115
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1866
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.940