DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and slc17a6a

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001009982.1	Gene:	slc17a6a / 494492	ZFINID:	ZDB-GENE-050105-4	Length:	587	Species:	Danio rerio

Alignment Length:	615	Identity:	275/615 - (44%)
Similarity:	359/615 - (58%)	Gaps:	73/615 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GYEEMEGGDREGRGPGGGHAYDDDDDRPDSPASFEEIERPPLRKIDKYCKAECPC--MPARYTIA 99
            |.|:|.  :..|:..|..|...:...:........|..||......|....:|.|  :|.||.||
Zfish    12 GKEKMR--NLAGKTLGHMHRVMERKQKTGEVIELTEDGRPMHMPEKKAPLVDCTCFGLPRRYIIA 74

  Fly   100 TMACVGFMIAFGMRCNMSAAKLKGEHNGTVF------------MNWTVAVESHVDSSFFWGYLVT 152
            .|:.:||.|:||:|||:..|.:...:|.|:.            .||.......:..||||||.||
Zfish    75 IMSGLGFCISFGIRCNLGVAIVDMVNNSTIHKGGKIIIKGKAKFNWDPETVGMIHGSFFWGYTVT 139

  Fly   153 QIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIW 217
            |||||:|:|:..||::||.:|:.::||::|:|.|..:.:| .|:.||:||||.||||||||||||
Zfish   140 QIPGGYISSRLAANRVFGAAILLTSTLNMFIPSAARVHYG-CVMFVRILQGLVEGVTYPACHGIW 203

  Fly   218 RFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFEN 282
            ..||||:|||||||.:|.|||||.||.:||:|:|....|:.:.||.||.|||:||||||.:.:|:
Zfish   204 SKWAPPLERSRLATTSFCGSYAGAVVAMPLAGILVQYSGWSSVFYIYGSFGIVWYMFWILVSYES 268

  Fly   283 PRKHPAISIPELKYIEKSLGESAH--PTMPSLKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVL 345
            |..||.|:..|..|||:|:||||.  ..|...| ||||:...||||||||||||||||.||||::
Zfish   269 PADHPTITDEERTYIEESIGESAKLLGAMEKYK-TPWRKFFTSMPVYAIIVANFCRSWTFYLLLI 332

  Fly   346 FQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFNCGGFGME 410
            .|.::.:..|||::.:.|.|.:||||:||.|||.||.|||:||...||:||.|||:.||||||||
Zfish   333 SQPAYFEEVFGFEISKVGMVSALPHLVMTIIVPIGGQLADYLRSKNILTTTTVRKIMNCGGFGME 397

  Fly   411 GLFFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVP 475
            ....|.|..|.:...|:..|...|.||||||||:|||||||||||||||||:|||:|||:|::.|
Zfish   398 ATLLLVVGFSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCP 462

  Fly   476 YALDGLIQANPTGCWTTVFTLAACVHLVGCTFYGIFASGELQPWAEPPAEEQKVWAPPPGAITNT 540
            ..:..:.:......|..||.:|:.||..|..|||||||||.||||:|  ||             |
Zfish   463 LIVGAMTKNKTREEWQNVFLIASLVHYGGVIFYGIFASGEKQPWADP--EE-------------T 512

  Fly   541 DPSQAGML---------GD-------YMKETSFGAPEYTEQSQMQQSTAISYGATGHVANNPFAM 589
            ...:.|.:         ||       :..:.:.|||            |.:||||..: |..:|.
Zfish   513 SDEKCGFIDEDELAEETGDITLSHAPFGAQGALGAP------------AKTYGATTQL-NGGWAK 564

  Fly   590 A-SGAPPIAEEDAPPTY-GDVTNPGQYGYT 617
            . .......:|||..|| ||       ||:
Zfish   565 GWEKTEEFIQEDAERTYTGD-------GYS 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	225/427 (53%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	211/387 (55%)
slc17a6a	NP_001009982.1	2A0114euk	70..512	CDD:129972	239/458 (52%)
slc17a6a	NP_001009982.1	MFS	75..499	CDD:119392	223/425 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582643
Domainoid	1	1.000	435	1.000	Domainoid score	I549
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121617
Inparanoid	1	1.050	501	1.000	Inparanoid score	I1329
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D144672at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		otm26323
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910