DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and CG9825

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_611723.3	Gene:	CG9825 / 37624	FlyBaseID:	FBgn0034783	Length:	485	Species:	Drosophila melanogaster

Alignment Length:	477	Identity:	136/477 - (28%)
Similarity:	211/477 - (44%)	Gaps:	39/477 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 PCMPARYTIATMACVGFMIAFGMRCNMSAAKLKGEHNGTVFMN-----WTVAVESHVDSSFFWGY 149
            |.:..|:..|.:..:.....|..|.|:..:.:...:..|...|     ||.|.:|::.|||||||
  Fly     9 PVLGMRHVQALLIFLNITTVFIGRLNVGVSVVAMTNAETTNPNFPEYDWTEAEKSYILSSFFWGY 73

  Fly   150 LVTQIPGGFIASKFPANK-----IFGLSIVSSATLHLFVPFAMTLMHGHVVIC-VRVLQGLFEGV 208
            ::||..||::..:|....     :|| |.|.||...||:.|.....:     | :|||.||.:||
  Fly    74 ILTQFLGGYLCKRFGVKSVMFWGVFG-SGVCSALTPLFIGFGEWQAY-----CGIRVLMGLAQGV 132

  Fly   209 TYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLA-DAVGYQAPFYAYGVFGIIWY 272
            .:|..|.....|:||.||:||..|:.:|...|.|..:.|||::| .::|:....|........|.
  Fly   133 VFPCIHQHLAKWSPPEERNRLGALSHTGIECGNVSAMFLSGMIAKSSLGWPGISYVSAGVAFFWC 197

  Fly   273 MFWIWLCFENPRKHPAISIPELKYIEKSL--GESAHPTMPSLKTTPWREMMRSMPVYAIIVANFC 335
            ..|......:|.:...|...||.|||.||  .||.|.|:..:   ||:.:..|.|..|:::....
  Fly   198 TLWFVFAANHPTESRFIGENELIYIESSLKHNESYHATIIPI---PWKAIWTSAPFLALLIVRCA 259

  Fly   336 RSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTNVRK 400
            .:|....|.....|::.......::...|..:||.|.|..:.....::||.|.....:|.|.:||
  Fly   260 ENWGLSTLQAEIPSYMNGVLDMDMKSNAFFSALPFLAMWCMSYIYLVVADVLLGKNSVSLTILRK 324

  Fly   401 LFNCGGF-----GMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYASILM 460
            .:|...|     .:.|:.||.....:.|...|   |..|..:.....|..:|.:|::..:|||||
  Fly   325 TYNSIAFWIPAATLVGIGFLDKEQKNFAIALM---TISVGVNSAQTIGSVLNTIDLSKNHASILM 386

  Fly   461 GLSNGIGTLAGIIVPYALDGLIQAN-PTGCWTTVFTLAACVHLVGCTFYGIFASGELQPW-AEPP 523
            |:.|.......|:.|..:..:::.| ....|..||.:|:.:..||...|.:|.:.|.||| ||..
  Fly   387 GIVNTAANFVPIVTPLVVGWIVKENSDRSQWQIVFIIASVIFFVGNCIYLVFGTAETQPWDAEDY 451

  Fly   524 AEEQKVWAPPPGAITNTDPSQA 545
            .:.|.      ..:.|..|.||
  Fly   452 LQTQN------PELANRPPMQA 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	122/433 (28%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	112/392 (29%)
CG9825	NP_611723.3	2A0114euk	14..450	CDD:129972	129/447 (29%)
CG9825	NP_611723.3	MFS	54..438	CDD:119392	116/395 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451953
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	8.000