DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and Slc17a5

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001009713.1	Gene:	Slc17a5 / 363103	RGDID:	1311388	Length:	495	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	179/503 - (35%)
Similarity:	268/503 - (53%)	Gaps:	53/503 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 RGPGGGHAYDDDDDRPDSPASFEEIERPPLRKIDKYCKAECPCMPARYTIATMACVGFMIAFGMR 113
            |||.|    :||::..||         .||....:..:|...|..|||.:|.:|..||.:.:.:|
  Rat     6 RGPAG----NDDEESSDS---------TPLLPSARQIEAAPACCSARYNLALLAFCGFFVLYALR 57

  Fly   114 CNMSAA---------------------------KLKGEHNGTVFMNWTVAVESHVDSSFFWGYLV 151
            .|:|.|                           |:...|.|..: .|....:..:..|||:||:|
  Rat    58 VNLSVALVDMVDSNSTLTDNRTSKECAEHSAPVKVHHNHTGKKY-QWDAETQGWILGSFFYGYIV 121

  Fly   152 TQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGHV-VICVRVLQGLFEGVTYPACHG 215
            ||||||::||:.....:.||.|:.:|...||.|.|..|  |.| :|.:|.|:||.||||:||.|.
  Rat   122 TQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADL--GVVALIVLRALEGLGEGVTFPAMHA 184

  Fly   216 IWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCF 280
            :|..||||:|||:|.|::::|:..|.|:.|||||::...:.:...||.:|:.||:|::.|:|:..
  Rat   185 MWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVS 249

  Fly   281 ENPRKHPAISIPELKYIEKSLGESAHPTMPSLKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVL 345
            :.|..|..||..|.:||..||...    :.|.|..||..:::|:|::||:||:|..:|.||.|:.
  Rat   250 DTPETHKTISHYEKEYIVSSLKNQ----LSSQKVVPWVSILKSLPLWAIVVAHFSYNWTFYTLLT 310

  Fly   346 FQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFNCGGFGME 410
            ...:::|....|.|:|.||:.:||:......:...|..||:||.....||.:||::|:.  .||.
  Rat   311 LLPTYMKEILRFNVQENGFLSALPYFGCWLCMIVCGQAADYLRVKWNFSTISVRRIFSL--IGMV 373

  Fly   411 GLFFLFVAHSSTATG---AMFALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGI 472
            |.....||.......   |:..||......|||.||:::|||||||.||.||:|::|...|:.|:
  Rat   374 GPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGM 438

  Fly   473 IVPYALDGLIQANPTGCWTTVFTLAACVHLVGCTFYGIFASGELQPWA 520
            |.|.....|...|....|.|||.:||.:::.|..|:.:||.||:|.||
  Rat   439 IGPIIAKSLTPDNTIKEWQTVFCIAAAINVFGAIFFTLFAKGEVQNWA 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	157/444 (35%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	145/404 (36%)
Slc17a5	NP_001009713.1	2A0114euk	30..491	CDD:129972	169/466 (36%)
Slc17a5	NP_001009713.1	MFS	99..478	CDD:119392	146/387 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342495
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750