DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and MFS17

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001015096.2	Gene:	MFS17 / 3354861	FlyBaseID:	FBgn0058263	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	477	Identity:	129/477 - (27%)
Similarity:	226/477 - (47%)	Gaps:	36/477 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 MPARYTIATMACVGFMIAFGMRCNMS---AAKLKGEHN-------------GTVFMNWTVAVESH 140
            :|||..:..::..||:::|.||.:|:   .|.:..:::             ||...:....|:|.
  Fly    33 IPARLVLYFLSWSGFLVSFMMRNDMNFALVAMIANDNSTQNQSLIKSQQILGTGTDDQKTIVKSV 97

  Fly   141 VDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGHVVICVRVLQGLF 205
            |.|||:|.|:::|:.||.....|....:||.|.:::|.....:|.|..| |...||.:|.:||..
  Fly    98 VISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMPSAAQL-HYIAVIVLRSIQGFA 161

  Fly   206 EGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGII 270
            .|:|:||.:.|..:|.|..||||..: :|.|...|:.:..||.|.:....|:...||..|..|:.
  Fly   162 SGLTWPAMYAIVGYWIPLTERSRFMS-SFQGFSIGIGLTYPLCGFILSEWGWPYIFYTTGTLGLG 225

  Fly   271 WYMFWIWLCFENPRKHPAISIPELKYIEKSLGESAHPTMPSLKT-TPWREMMRSMPVYAIIVANF 334
            |.:.|..|.|..||:||.|:..||.|||.::.:..:   .|:|. .||.::.:|:|.:||.:..|
  Fly   226 WCILWYLLAFNTPREHPRITKDELNYIELNVKKEVN---SSVKVKVPWLQIFKSIPAWAIAITTF 287

  Fly   335 CRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHL---IMTTIVPFGGMLADHLRKNGILSTT 396
            .|.:..|:.::...:|:.:...|..|..||:..:|.:   |.:.:..:   :||.:....:|..|
  Fly   288 GRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFCY---IADKIVFYKVLCLT 349

  Fly   397 NVRKLFNCGGFGMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRY--ASIL 459
            ||||:|......:.|:....:.:.......:......|.|...:.:|...|.:|:||.|  ::.:
  Fly   350 NVRKVFTALSQIIPGVLIYCIGYIDNVYILLTVWFIAVIFITASYAGAMANIIDLAPNYGHSAAV 414

  Fly   460 MGLSNGIGTLAGIIVPYALDGLI-QANPTGCWTTVFTLAACVHLVGCTFYGIFASGELQPW---- 519
            :.....|...|..|.|.....:: |.:....|..||.::|.:.::...||.:|.:.|:|.|
  Fly   415 LAFCQTIHMSASFISPLTAGFIVTQEDSIDQWRRVFEVSAIISILTYLFYQLFGTAEIQTWNKGL 479

  Fly   520 -AEPPAEEQKVWAPPPGAITNT 540
             ....::|.||.:.....:.||
  Fly   480 PVNDDSDEGKVLSTAKDDLDNT 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	117/436 (27%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	109/395 (28%)
MFS17	NP_001015096.2	2A0114euk	34..477	CDD:129972	124/450 (28%)
MFS17	NP_001015096.2	MFS	41..467	CDD:119392	117/433 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.070