DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and MFS3

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_608572.1	Gene:	MFS3 / 33292	FlyBaseID:	FBgn0031307	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	134/498 - (26%)
Similarity:	229/498 - (45%)	Gaps:	72/498 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 MPARYTIATMACVGFMIAFGMRCNMSAAKL----------------KGEHNGTVFMN-------- 132
            :||||.:|.:..:|..|.:|::.|:|.|.:                .|.|...:..|
  Fly    16 VPARYVLALLGSIGMAIVYGLKVNLSVAMVAMVNHTAIKAHGDGGGHGGHGSVILSNASQVSLVE 80

  Fly   133 ---------------------WTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSS 176
                                 |:..::..:.|.:||||||:|||...:|..|.|..:...|:..:
  Fly    81 ECNPPGGASNVTAKVEDGPFDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAIN 145

  Fly   177 ATLHLFVPFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGV 241
            ....|..|....|.:|.::: :|||:|:..|.::||.|.:...||||.||..::|:.:.|:.||.
  Fly   146 VVCTLLTPVFTELHYGGLIL-MRVLEGVGGGASFPAMHVMIASWAPPTERMVMSTIIYVGTSAGT 209

  Fly   242 VVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGESA- 305
            .:.:.|:|:.:...|:::.||..|....||.:.|:.|..:||.|...||:.|.:.|..|||...
  Fly   210 ALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVQDNPNKQRFISLEERQMITSSLGTEQK 274

  Fly   306 ---HPTMPSLKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGS 367
               ||.:      ||.::..|:|.:||::|:.|.::.:|:.::....::|....|.|.....:.:
  Fly   275 TEHHPAV------PWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSA 333

  Fly   368 LPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFN--C---GGFGMEGLFFLFVAHSSTATGAM 427
            ||:..|.......|.|.|.|:..|.::||..||...  |   .|..:..|.::...|..    |:
  Fly   334 LPYFPMIIFSICLGKLLDSLQAKGKITTTVARKTATSICTLIPGVCLLVLCYIGCRHYE----AV 394

  Fly   428 FALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPT-GCWT 491
            ..::.|:...|...||:..||:||||.:|..|:.|:|...||.||:||..:..:.:.|.. |.|.
  Fly   395 SVMSVGIVAMGSMFSGFLSNHIDIAPNFAGTLVALTNTAATLPGIVVPLFVGFVTKGNQNIGAWR 459

  Fly   492 TVFTLAACVHLVGCTFYGIFASGELQPW------AEPPAEEQK 528
            .:|.:...:..:....:....||..|||      .:|.|:::|
  Fly   460 IIFGVTIVLFALEFLVFVFLGSGSEQPWNKAGTPKDPEAKDEK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	122/468 (26%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	115/427 (27%)
MFS3	NP_608572.1	2A0114euk	19..489	CDD:129972	129/480 (27%)
MFS3	NP_608572.1	MFS	100..479	CDD:119392	112/389 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.070