DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and CG6978

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_572188.1	Gene:	CG6978 / 31413	FlyBaseID:	FBgn0029727	Length:	479	Species:	Drosophila melanogaster

Alignment Length:	488	Identity:	152/488 - (31%)
Similarity:	241/488 - (49%)	Gaps:	55/488 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 DDDDRPDSPASFEEIERPPLRKIDKYCKAECPCMPARYTIATMACVGFMIAFGMRCNMSAAKL-- 121
            |.:.|.:..||..:|.|               |...|:.:..|...|...|:.||.|||.|.:
  Fly    20 DQEVRMERYASDGQIPR---------------CRKTRFFVVLMLFSGMANAYVMRTNMSVAIVAM 69

  Fly   122 --------------KGEHNGTVFMNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLS 172
                          ..|.:|.  ..|:..::.::.||||:||::||||.|.:...:.|....|..
  Fly    70 VNHTAISHTKSSTQSKERDGD--FEWSYKLQGYILSSFFYGYVITQIPFGLMIKYYGARHFLGWG 132

  Fly   173 IVSSATLHLFVPFAMTLMHGHVV-IC-VRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFS 235
            ::.::....|:|  ::...|.|| :| ||.:|||.||...|..|.:...|.||.|||......::
  Fly   133 MMINSLAAFFIP--ISARSGGVVGLCVVRFIQGLGEGPIVPCSHSLLAQWVPPNERSLAGAAVYA 195

  Fly   236 GSYAGVVVGLPLSGLLA----DAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKY 296
            |:..|.:|.:|||||||    |. |:.:.||.:|:|..||.:.:|.|..|:|.....||..|.::
  Fly   196 GAQFGTIVSMPLSGLLAHYGFDG-GWPSIFYIFGLFSTIWCIIFICLVQESPAVSTRISEAERRH 259

  Fly   297 IEKSLGESAHPTMPSLKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEE 361
            |.:::.: |.|...|  ..|:..:.:|.|.|||:||:...::.:..|:....:::.......:..
  Fly   260 IMEAIWQ-AQPEERS--RIPFLGIAKSPPFYAILVAHAGHNYGYETLMTMLPTYMYRVLNVNIRT 321

  Fly   362 AGFVGSLPHLIMTTIVPFGGMLADHL-RKNGILSTTNVRKLFN-CGGFG--MEGLFFLFVAHSST 422
            .|.:.|||:|.|..:....|:|||.| |:|  .|.|.||||.| .|.:|  :..:...||.||..
  Fly   322 NGIISSLPYLAMWILAIVFGILADCLIRRN--FSITVVRKLMNSLGQYGPAVALISVGFVHHSLW 384

  Fly   423 ATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPT 487
            .|..:|.|  |:..:|....|:.:||||::||:|.:|:.::|.:..|.|::.|.....:|...|:
  Fly   385 LTSVIFIL--GMGLNGAIYCGFKINHLDLSPRFAGLLISVTNCVANLVGLMAPMVAGHVIDPKPS 447

  Fly   488 -GCWTTVFTLAACVHLVGCTFYGIFASGELQPW 519
             ..|..||.:||.|.:...:||.:||||: |.|
  Fly   448 VENWRIVFYIAAGVFIFTASFYNVFASGK-QQW 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	138/440 (31%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	127/399 (32%)
CG6978	NP_572188.1	2A0114euk	38..478	CDD:129972	143/452 (32%)
CG6978	NP_572188.1	MFS	45..473	CDD:119392	138/439 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452014
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900