DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and Slc17a8

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_714947.1	Gene:	Slc17a8 / 266767	RGDID:	628870	Length:	588	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	266/590 - (45%)
Similarity:	356/590 - (60%)	Gaps:	64/590 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FKEKATGVFGGLKPNME--KFEISQSYHGGHGG--YEEMEGGDREGRGPGGGHAYD-DDDDRPDS 66
            ||||.      |||..|  |..:..|.     |  ..:::|.:.|      |.|.: .::.||..
  Rat     9 FKEKI------LKPGKEGVKNAVGDSL-----GILQRKLDGTNEE------GDAIELSEEGRPVQ 56

  Fly    67 PASFEEIERPPLRKIDKYCKAECPCMPARYTIATMACVGFMIAFGMRCNMSAAKLKGEHNGTVFM 131
            .:.    .|.|:      |...|..:|.||.||.|:.:||.|:||:|||:..|.::..:|.||::
  Rat    57 TSR----ARAPV------CDCSCCGIPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYV 111

  Fly   132 -----------NWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPF 185
                       ||.......:..||||||:|||||||||::||.||::||.:|..::||::|:|.
  Rat   112 DGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPS 176

  Fly   186 AMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGL 250
            |..:.:| .|:|||:||||.||||||||||:|..||||:|||||||.:|.|||||.||.:||:|:
  Rat   177 AARVHYG-CVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGV 240

  Fly   251 LADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGESAHPTMPSLKTT 315
            |...:|:.:.||.||:|||||||||:...:|.|..||.||..|..|||.|:||.|:....|...|
  Rat   241 LVQYIGWASVFYIYGMFGIIWYMFWLLQAYECPAVHPTISNEERTYIETSIGEGANLASLSKFNT 305

  Fly   316 PWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFG 380
            |||....|:||||||||||||||.||||::.|.::.:..|||.:.:.|.:.::||::||.:||.|
  Rat   306 PWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIG 370

  Fly   381 GMLADHLRKNGILSTTNVRKLFNCGGFGMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISGYN 445
            |.|||:||...||:||.|||:.||||||||....|.|..|.|...|:..|...|.||||||||:|
  Rat   371 GQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFN 435

  Fly   446 VNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPTGCWTTVFTLAACVHLVGCTFYGI 510
            ||||||||||||||||:|||:|||:|::.|..:..:.:......|..||.:||.||..|..|||:
  Rat   436 VNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGV 500

  Fly   511 FASGELQPWAEPPAEEQKVWAPPPGAITNTDPSQAGMLG-DYMKETSFGAPEYTEQSQMQQSTAI 574
            |||||.|.||:|               .|....:.|::. |.:.|.:    |...::.:.....:
  Rat   501 FASGEKQDWADP---------------ENLSEEKCGIIDQDELAEET----ELNHEAFVSPRKKM 546

  Fly   575 SYGAT 579
            |||||
  Rat   547 SYGAT 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	223/424 (53%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	209/384 (54%)
Slc17a8	NP_714947.1	MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	222/423 (52%)
Slc17a8	NP_714947.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..588		5/13 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342513
Domainoid	1	1.000	440	1.000	Domainoid score	I529
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1323
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D144672at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		otm46209
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910