DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and SPAC11D3.18c

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001342807.1	Gene:	SPAC11D3.18c / 2543005	PomBaseID:	SPAC11D3.18c	Length:	498	Species:	Schizosaccharomyces pombe

Alignment Length:	512	Identity:	113/512 - (22%)
Similarity:	194/512 - (37%)	Gaps:	136/512 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 EIERPPLRKIDKYCKAECPCMPARYTIATMACVGF--MIAFGMRCNM---------SAAKLKGEH 125
            ::|:..|.|:|               :.....:||  ::||..|.|:         .|..|.||.
pombe    48 KVEKKLLLKMD---------------LVISPIIGFLYLMAFLDRSNIGNAAVAGMTEALSLYGER 97

  Fly   126 NGTVFMNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFG-LSIVSSATLHLFVPFAMTL 189
                 :|..|::       |:..|::.:.|...:..:..|:::.. :|...|.|: ||..| |:.
pombe    98 -----LNVAVSI-------FYVLYILVETPSVVLVKRIKASRMLAFISFAWSMTV-LFSGF-MSS 148

  Fly   190 MHGHVVICVRVLQGLFEGVTYPACH-GIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLAD 253
            ..|  :|..|::.||.||..:||.: .:...:....:..||:.|..|...||.     ..||.|.
pombe   149 YGG--LIATRLILGLLEGCLFPALNLYLTTHYTRKEQCQRLSYLFASAGLAGA-----FGGLFAY 206

  Fly   254 AV---------GYQAPFYAYGVFGIIWYMFWIWLC-------FEN----PRKHPAISIPELKYIE 298
            |:         |:|   :.|.|.|::.:: .:.||       .||    .|:...::|     |.
pombe   207 ALEQVHAGNKEGWQ---WIYIVEGLVSFI-GVPLCLFALPDKMENAWFLTREEREVAI-----IR 262

  Fly   299 KSLGESAHPTMPSLKTTPWREMMRSM---PVYAIIVANFCRSWNFYLLVLFQ-SSFLKHKFGFKV 359
            :.:....|    ..:...|.|:.::.   .||....:.||..     :||:. ||||.    ..:
pombe   263 RDINARYH----GEQHFEWSEVRKAFKDPKVYVSATSQFCAD-----MVLYGFSSFLP----VII 314

  Fly   360 EEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFNCGGFGMEGLFFLFVAHSSTAT 424
            :..|||| |....||..|...|::: .|....:...|.:|.::......:..:.::.:. :|.:.
pombe   315 KGLGFVG-LQTNYMTIPVYIAGVIS-FLFVAWLSDRTQLRAVYLISASTVVAVGYIIML-ASDSN 376

  Fly   425 GAMFALTCGVAFSGFAISGYNVNHL--DIAPRY-----ASILMGLSNGIGTLAGII-----VPYA 477
            .|.:..|..:|...:...|.|:..|  ::|..|     ..|...|:|..|.:||.|     .|..
pombe   377 AAKYTATYIIAIGCYIGPGLNLGWLNNNVAGHYKRATAIGIQQTLANSSGIVAGQIYRSKNAPKY 441

  Fly   478 LDGLIQANPTGCWTTVFTLAACVHLVGCTFYGIF--------------ASGELQPWA 520
            :.|           ..||| .||.:.|..:..:|              |.||..|.|
pombe   442 ILG-----------NAFTL-GCVIVGGLAYVVMFFSLRYVNKKRDERCARGEFDPSA 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	104/476 (22%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	95/422 (23%)
SPAC11D3.18c	NP_001342807.1	UhpC	68..461	CDD:332119	101/450 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	69	1.000	Domainoid score	I2672
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I1933
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.050