DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and SPAC1039.04

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_594995.1	Gene:	SPAC1039.04 / 2542960	PomBaseID:	SPAC1039.04	Length:	507	Species:	Schizosaccharomyces pombe

Alignment Length:	517	Identity:	109/517 - (21%)
Similarity:	162/517 - (31%)	Gaps:	186/517 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 RCNMSAAKLKG--EHNGTVFMNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVS 175
            :.|:|.||..|  :..|.|...:.:.:     |.|:..:::...|..::..:|.|.:|....::|
pombe    76 KSNVSNAKTNGMDKDLGFVGDQYNIMI-----SIFYIPFVLCAFPFSYLYKRFGAARILPFFMLS 135

  Fly   176 SATLHLFVPFAMTLMHGHV-----VICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLA-TLAF 234
            ..        ||:|....|     ::.||...|:.|....|   |:..:......|:.|| .||.
pombe   136 FG--------AMSLCQAAVKNFGGMMAVRWFLGMAESAVLP---GVVYYLTTFYRRTELARRLAI 189

  Fly   235 SGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGII------W-YMFWI-----WLC-------- 279
              .||...|.....|||           |||||.|.      | |:|.|     :||
pombe   190 --FYAAANVSSAFGGLL-----------AYGVFHIKGGKLQGWQYLFLIEGGVTFLCAIVIFLVL 241

  Fly   280 ---------------------FENPRKHPAISIPELKYIEKSLGESAHPTMPSLKTTPW--REMM 321
                                 .||   ..:.:|.|....::||....||.     ...|  .||.
pombe   242 PVSVETANFLTDEEKTLAKMRIEN---DSSSAISEKLSFKQSLTVFKHPI-----AILWLLEEMA 298

  Fly   322 RSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGG----- 381
            ..:|:.:|         |.:|..:             |...|| .|:...:||......|
pombe   299 LGVPLNSI---------NNWLPQI-------------VAAMGF-SSVNTNLMTVAPAISGAIWLL 340

  Fly   382 ---MLADHLRKNGI-----LSTTNVRKLFNCGGFGMEGLFFLFVAHSSTATGAMFALTCGVAFSG 438
               .::|.|:..||     :|||.:       ||.:.|...: :.|...:..|.|.:|.|.|.|.
pombe   341 VFAFISDFLKNRGIVLIAAISTTMI-------GFIVYGSIDI-MNHIGVSYFACFLMTAGAAASS 397

  Fly   439 FAISGY------------------------------NVNHLDIAPRYASILMGLSNGIGTL---- 469
            ...|.:                              |:.....||:|...| |::.|.|.|
pombe   398 VLTSTWYNNNTPNESRRAVFTSVGVPLANVMGLVSANIFRPQDAPKYVPAL-GITAGFGGLGILL 461

  Fly   470 -AGIIVPYALDGLIQANPTGCWTTVFTLAACVHLVGCTFYGIFASGELQPWAEPPAEEQKVW 530
             |.|.|....|...:.|..|...|                  ||....:...|.||.....|
pombe   462 VASISVYMFFDNRRRDNAQGVKKT------------------FADVSTKDLGEGPANPNFRW 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	103/497 (21%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	98/460 (21%)
SPAC1039.04	NP_594995.1	MFS	71..471	CDD:119392	99/463 (21%)
SPAC1039.04	NP_594995.1	2A0114	71..463	CDD:273326	96/455 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	69	1.000	Domainoid score	I2672
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I1933
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.050