DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VGlut and SPCC757.13

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_587688.1	Gene:	SPCC757.13 / 2539039	PomBaseID:	SPCC757.13	Length:	522	Species:	Schizosaccharomyces pombe

Alignment Length:	554	Identity:	121/554 - (21%)
Similarity:	192/554 - (34%)	Gaps:	154/554 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EKATGVFGGLKPNMEKFEISQSYHGGHGGYEEMEGGDREGRGPGGGHAYDDDDDRPDSPASFEEI 73
            ||.:||....|.:.|..|:.:.             .|.||...........|||...:......:
pombe    18 EKKSGVTNDFKNSFEVGEVKRL-------------PDAEGTADAVAQELLADDDFTYTAKEARRV 69

  Fly    74 ERPPLRKIDKYCKAECPCMPARYTIATMACVGFMIAFGMRCNMSAAKLKGEHNGTVFMNWTVAVE 138
                |.|||      ...||       :.|:.:||.:..:..:|.|.|.|       |.....::
pombe    70 ----LWKID------LVMMP-------VMCITYMIQYLDKTALSYAALYG-------MKTDTHID 110

  Fly   139 SHVDSS----FFWGYLVTQIPGGFIASKFPANK-IFGLSIVSSATLHLFVPFAMTLM-----HGH 193
            .|..||    |:.||||.|.|...:..|...:. ||         .::|:..||..:     :|.
pombe   111 GHTYSSMTTLFYAGYLVAQYPAAILMQKCRLSYFIF---------CNVFLWSAMVCLMAACRNGP 166

  Fly   194 VVICVRVLQGLFEGVTYPACHGIWRFW----APPMERSRLATLAFSG--SYAGVVVGLPLSGLLA 252
            .::.:|.|.|:||....||...|...|    ..||.  .|...||:|  ...|.::...|..:..
pombe   167 SLLGLRFLAGIFEASITPAFINITAMWYRREEQPMR--TLCWYAFNGIAQIIGSILSYGLGHIHG 229

  Fly   253 DAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGESAHPTMPSLKTTPW 317
            ....::..|...|:..:.|.:.::::. .||.|...:|..|    ::...|........|:...:
pombe   230 KVASWRYVFIVIGLMSLGWGVVFVFIP-SNPSKARFLSSRE----KRIALERVRDNRTGLENKQF 289

  Fly   318 REMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGM 382
            :                   |             ||.:     || |:.  |.:||.|:.....|
pombe   290 K-------------------W-------------KHAY-----EA-FLD--PQVIMITLFTGVCM 314

  Fly   383 LADHLRKNGILSTTNVRKLFNCGGFGMEGLFFLFVAHSST--------ATGAMF--ALTCGVAFS 437
            :.:.:   |:.||..::      |.|...|      ||:.        ...|||  .:.|.|..:
pombe   315 ITNGI---GVFSTLIIK------GLGYNEL------HSAVLNMPLGAIEVAAMFISGVLCKVFKN 364

  Fly   438 GFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGI----IVPYA---LDGLIQANPTGCWTTVFT 495
            |..:.|..:|.|.:|.......:..||..|.|.|:    .||.:   |..||.:|..| :|....
pombe   365 GRLLIGVFMNCLTLAGCLMIWKIPDSNPYGRLVGVWFTMWVPASSALLLSLISSNVAG-YTKKTV 428

  Fly   496 LAACVHLVGCTFYGI--------FASGELQPWAE 521
            .:|.|.:    ||.:        |.||:...:.|
pombe   429 TSATVFV----FYSVGNIVSPQLFKSGQTPEYIE 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	98/454 (22%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	86/403 (21%)
SPCC757.13	NP_587688.1	MFS	80..477	CDD:119392	102/462 (22%)
SPCC757.13	NP_587688.1	2A0114	83..478	CDD:273326	101/459 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	69	1.000	Domainoid score	I2672
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I1933
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.050