Protein Alignment VGlut and Slc17a8

DIOPT Version :9

• Sequence 1: NP_001245848.1
• Gene: VGlut / 33427
• FlyBaseID: FBgn0031424
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_892004.1
• Gene: Slc17a8 / 216227
• MGIID: 3039629
• Length: 601
• Species: Mus musculus
• Alignment Length: 612
• Identity: 267/612 - (43%)
• Similarity: 349/612 - (57%)
• Gaps: 85/612 - (13%)

  Fly     2 KGLTAFKEKATGVFGGLKPNME--------KFEISQSYHGGHGGYEEMEGGDREGRGPGGGHAYD 58
            |....||||.      |||..|        ...|.|....|....|:....:.|||
Mouse     4 KAFDTFKEKI------LKPGKEGVKNAVGDSLGILQRKIDGTNEEEDAIELNEEGR--------- 53

  Fly    59 DDDDRPDSPASFEEIERP---------PLRKIDKYCKAECPCMPARYTIATMACVGFMIAFGMRC 114
                    |.......||         |.|.|   |...|..:|.||.||.|:.:||.|:||:||
Mouse    54 --------PVQTSRAHRPVCDCSCCGIPKRYI---CDCSCCGIPKRYIIAVMSGLGFCISFGIRC 107

  Fly   115 NMSAAKLKGEHNGTVFM-----------NWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKI 168
            |:..|.::..:|.||::           ||.......:..||||||:|||||||||::||.|:::
Mouse   108 NLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAASRV 172

  Fly   169 FGLSIVSSATLHLFVPFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLA 233
            ||.:|..::||::|:|.|..:.:| .|:.||:||||.||||||||||:|..||||:|||||||.:
Mouse   173 FGAAIFLTSTLNMFIPSAARVHYG-CVMGVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTS 236

  Fly   234 FSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIE 298
            |.|||||.||.:||:|:|...:|:.:.||.||:|||||||||:...:|.|..||.||..|..|||
Mouse   237 FCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNAERTYIE 301

  Fly   299 KSLGESAHPTMPSLKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAG 363
            .|:||.|:....|...||||....|:||||||||||||||.||||::.|.::.:..|||.:.:.|
Mouse   302 TSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVG 366

  Fly   364 FVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFNCGGFGMEGLFFLFVAHSSTATGAMF 428
            .:.::||::||.:||.||.|||:||...||:||.|||:.||||||||....|.|..|.|...|:.
Mouse   367 LLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAIS 431

  Fly   429 ALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPTGCWTTV 493
            .|...|.||||||||:|||||||||||||||||:|||:|||:|::.|..:..:.:......|..|
Mouse   432 FLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNV 496

  Fly   494 FTLAACVHLVGCTFYGIFASGELQPWAEPPAEEQKVWAPPPGAITNTDPSQAGMLGDYMKETSFG 558
            |.:||.||..|..|||:|||||.|.||:|               .|....:.|::..
Mouse   497 FLIAALVHYSGVIFYGVFASGEKQDWADP---------------ENLSEDKCGIIDQ-------- 538

  Fly   559 APEYTEQSQMQQSTAI------SYGAT 579
             .|..|::::...|.:      |||||
Mouse   539 -DELAEETELNHETFVSPRKKMSYGAT 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	221/424 (52%)
		MFS_1	101..475	CDD:284993	207/384 (54%)
Slc17a8	NP_892004.1	2A0114euk	88..526	CDD:129972	232/453 (51%)
		MFS	93..515	CDD:119392	219/422 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..601

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	440	1.000	Domainoid score	I548
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1363
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D144672at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		otm44115
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1866
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.010