DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and F59A1.13

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_507475.2	Gene:	F59A1.13 / 186565	WormBaseID:	WBGene00010299	Length:	494	Species:	Caenorhabditis elegans

Alignment Length:	509	Identity:	115/509 - (22%)
Similarity:	200/509 - (39%)	Gaps:	102/509 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 SPASFEEIE------RPPLRKIDK---------YCKA---ECPCMPARYTIA---TMACVGFMIA 109
            |..|.:|.|      ..|.||:.|         |...   .|..:....::|   |:.|:..::.
Worm    27 SQESLKEFEFSRQNFGGPKRKVSKNVLGHRTRWYIMVVLLSCLTLNQMNSVAYSFTVICMDDLVE 91

  Fly   110 FGMRCNMSAAKLKGEHNGTVFMNWTVAVESHVDSSFFW-----GYLVTQIPGGFIASKFPANKIF 169
                 ...|..|.|.|       |   :||..:.|..:     |.::..:|...:........:.
Worm    92 -----EHHARNLTGHH-------W---MESSTEKSLIFSATAIGAVMGLVPSVPLIDSLGIRGVL 141

  Fly   170 GLSIVSSATLHLFVPFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAF 234
            .:|...||...||.||::......|:.| ||||||...|.......|...|||..|......:..
Worm   142 SISGAFSALGTLFFPFSVDSNIYAVIFC-RVLQGLGVSVIMTVVGVIPGTWAPTSETGTFMAILS 205

  Fly   235 SGSYAGVVVGLPLSGLLADA-VGYQAPFYAYG----VFGIIWYMFWIWLCFENPRKHPAISIPEL 294
            ......:::.:|:||.|.:: .|:::.:|.:|    :|..|:|:|:.    ::||.|..:|..||
Worm   206 CVFQLSMIICMPVSGFLCESRFGWRSIYYIFGGSTIIFYAIFYIFYT----DSPRFHRNVSEKEL 266

  Fly   295 KYIEKSLGESAHPTMPSLKTTPWREMMRSMPVYAII---------VANFCRSWNFYLLVLFQSSF 350
            |.||....|.               :...:|.:||.         ::.|..::.|.:|.|:..::
Worm   267 KKIEDGKMEI---------------VKEGVPYWAICTDGTVLVGWLSVFGGNFGFTILTLYGPTY 316

  Fly   351 LKHKFGFKVEEAGFVGSLPHLIMTTIVPF-GGMLADHLRKNGILSTTNVRKLFNCGGFGMEG--- 411
            ||....|.|::.||..:|| .|::.:..| .|.::|.:.    ..|..:|  |:......:|
Worm   317 LKDVLNFDVKKTGFATALP-FILSALSKFAAGRISDRMD----FLTEKMR--FSVCTIVSQGSVV 374

  Fly   412 LFFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPR----YASILMGL---SNGIGT- 468
            :..|.:|.:.....|.||.|..:..||.:|.| |:..:.:..|    :|..:..|   :|..|.
Worm   375 IGLLLMAMTENWRIAQFAYTFAITASGLSIVG-NIKCIQLRCRQHTHFALTVSSLGIYANYFGAP 438

  Fly   469 -LAGIIVPYALDGLIQANPTGCWTTVFTLAACVHLVGCTFYGIFASGELQPWAE 521
             :.||:...|      .|....|:.:|.:.|.|.::....:....|.|..|:.:
Worm   439 IVVGILTSAA------GNTAENWSHLFIIVAVVTVITNAPFPFLTSDEPGPYVK 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	102/448 (23%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	94/405 (23%)
F59A1.13	NP_507475.2	MFS	106..473	CDD:391944	93/400 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910