DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and slc-17.5

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_505139.1	Gene:	slc-17.5 / 184790	WormBaseID:	WBGene00017681	Length:	530	Species:	Caenorhabditis elegans

Alignment Length:	416	Identity:	102/416 - (24%)
Similarity:	180/416 - (43%)	Gaps:	15/416 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 GMRCNMSAAKLKGEHNGTVFMNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVS 175
            |..|.....|:..::.||..  |:|:.:.::.|:.|.|..:...|.|.:..:|.|..|..::|:.
Worm    97 GESCTKLEGKVIKDYGGTFI--WSVSWQGYIVSAAFLGGFIFSYPAGVLVDRFSARHILSVAILM 159

  Fly   176 SATLHLFVPFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGS-YA 239
            .....|.:|.....:........|.:.|:.|.:..|:.:.:...|.|..|:|..|::..:|: .:
Worm   160 LTIASLLMPVLSIYIGEKGAFAGRFVMGISETMLIPSINSMVTKWIPINEKSLAASVFTAGNQLS 224

  Fly   240 GVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGES 304
            |:...:.::.|.|.:.|:.:.||:..:|||.|.:.|......:|.....|...||.|    |..:
Worm   225 GMFGNILVAELCASSFGWSSIFYSASLFGISWLVLWHLTVRNSPHNTRWIHKRELDY----LANN 285

  Fly   305 AHPTMPS--LKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGS 367
            ..|..||  :|.||||:|:.|...::::..:...:....|:.::...:.|......|:..||..:
Worm   286 IPPKHPSSVVKKTPWRDMLTSKVFWSLMFNSVMGNMMIALIFVYIPVYFKDVLMLDVQSNGFYSA 350

  Fly   368 LPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFNCGGFGMEGL----FFLFVAHSSTATGAMF 428
            :||:.........|.|.|.:|...|||.:...||....  .|.|:    |||...:.:|...|:.
Worm   351 IPHISNLIAKLIWGYLMDKMRHKKILSPSATVKLSQFA--SMMGISVSCFFLRYMNCATPFYALV 413

  Fly   429 ALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPTGCWTTV 493
            .|:...||.|.:|||:..:.|.|||.:...|..|:..||.:..:..|..:...........|..|
Worm   414 LLSSVSAFFGLSISGFYTSLLSIAPSHIGTLTSLATVIGFVGRMFTPLMISYYKTVGTAEEWGHV 478

  Fly   494 FTLAACVHLVGCTFYGIFASGELQPW 519
            ..:.......|...:.:|.||::|.|
Worm   479 LLIYVFASATGGIIFLLFGSGDVQNW 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	97/407 (24%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	93/370 (25%)
slc-17.5	NP_505139.1	MFS	108..497	CDD:391944	94/396 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920