DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and vglu-3

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_499277.1	Gene:	vglu-3 / 176442	WormBaseID:	WBGene00011556	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	467	Identity:	185/467 - (39%)
Similarity:	263/467 - (56%)	Gaps:	40/467 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LRKIDKYCKAECPCMPARYTIATMACVGFMIAFGMRCNMSAAKLK---------GEHNGTVFMNW 133
            |||:             |:.||.:|..||.|:||:|.|...||.:         ||.:...|: |
Worm    43 LRKV-------------RWQIAILAHFGFAISFGIRSNFGVAKNRMVNNFTDAYGEVHEREFL-W 93

  Fly   134 TVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGHV---V 195
            |.|....::||||:||..:|||.|.:|:||..||||.|.|:.::.:::....:.. .|.:.   |
Worm    94 TGAEVGMMESSFFYGYAASQIPAGVLAAKFAPNKIFMLGILVASFMNILSAISFN-FHPYTDIFV 157

  Fly   196 ICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAP 260
            :.|:.:|||..||.|||.||:|:|||||:|||:|||.||:||..||:.|||.|..|.....:..|
Worm   158 MVVQAVQGLALGVLYPAMHGVWKFWAPPLERSKLATTAFTGSSVGVMTGLPASAYLVSHFSWSTP 222

  Fly   261 FYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGESAHPTMPSLKTTPWREMMRSMP 325
            ||.:||.||||.:.|:::...:|..|..||..|.|.:.:.:|:.|...| ||.|.|||:||.|..
Worm   223 FYVFGVVGIIWSLIWMYVSSHSPETHGYISDDEKKQVTEKIGDVAVKNM-SLTTLPWRDMMTSSA 286

  Fly   326 VYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKN 390
            |:|||:..|||||.|:||:..|.:::|......::.:||:...|...|..:....|.|.|:||.:
Worm   287 VWAIIICTFCRSWGFFLLLGNQLTYMKDVLHIDIKNSGFISIFPQFGMCIVTLATGQLCDYLRSS 351

  Fly   391 GILSTTNVRKLFNCGGFGMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRY 455
            |.:||..|||..|..||.:|.:....:|.......|:..|......||..:||:||||.||||||
Worm   352 GKMSTEAVRKSVNTFGFTVEAMMLGCLAFVRDPVIAVTCLVIACTGSGSVLSGFNVNHFDIAPRY 416

  Fly   456 ASILMGLSNGIGTLAGIIVPYALDGLI-----QANPTGCWTTVFTLAACVHLVGCTFYGIFASGE 515
            |.||||::||:|.:||:      .|::     ..||.| |..||.||..:.:.|..|:.|||.|:
Worm   417 APILMGIANGLGAVAGV------GGMVTNTVTYQNPDG-WKWVFLLAMAIDIFGVIFFLIFAKGD 474

  Fly   516 LQPWAEPPAEEQ 527
            :.|||..|.:|:
Worm   475 VLPWAREPEKEE 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	173/430 (40%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	159/385 (41%)
vglu-3	NP_499277.1	2A0114euk	47..485	CDD:129972	181/447 (40%)
vglu-3	NP_499277.1	MFS	52..471	CDD:119392	171/428 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D144672at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.030