DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and vglu-2

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_499276.1	Gene:	vglu-2 / 176441	WormBaseID:	WBGene00010755	Length:	573	Species:	Caenorhabditis elegans

Alignment Length:	478	Identity:	188/478 - (39%)
Similarity:	270/478 - (56%)	Gaps:	44/478 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 SFEEIERPPLRKIDKYCKAECPCMPARYTIATMACVGFMIAFGMRCNMSAAKLK---------GE 124
            |.:|..:..|||:             |:.||.:|..||.|:||:|.|...||.:         ||
Worm    34 SLQEDNKFFLRKV-------------RWQIALLAHFGFAISFGIRSNFGVAKNRMINNFTDAYGE 85

  Fly   125 -HNGTVFMNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHL------- 181
             |....|  ||......::||||:||..:|||.|.||:||..||:|.|.|:.::.|::
Worm    86 VHEKEFF--WTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLN 148

  Fly   182 FVPFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLP 246
            |.||....     |:.::|:|||..||.|||.||:|::||||:|||:|||..|:|:..||:||||
Worm   149 FHPFTDIF-----VMVIQVMQGLALGVCYPAMHGVWKYWAPPLERSKLATTTFTGASVGVMVGLP 208

  Fly   247 LSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGESAHPTMPS 311
            .|..|.....:..|||.:|..||:|.:.||::...:|..|..||..|.|||.:.:|..|...| :
Worm   209 ASAYLVSHFSWSTPFYVFGALGIVWSILWIYVSGTSPETHGYISADEKKYITEKVGSVAVKNM-T 272

  Fly   312 LKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTI 376
            |.|.|||:||.|..|:|||:.:|||||:|:||:..|.:::|......::.:|.:...|.|.|..:
Worm   273 LTTLPWRDMMTSTAVWAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLGMCIV 337

  Fly   377 VPFGGMLADHLRKNGILSTTNVRKLFNCGGFGMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAI 441
            ....|.|:|:||.:|.:||..|||..|..||.:|.:....:|.......|:..|....:.:|..:
Worm   338 TLTSGQLSDYLRSSGKMSTEAVRKSVNTFGFTVEAVMLGCLAFVRDPVIAVTFLIIACSGAGAVL 402

  Fly   442 SGYNVNHLDIAPRYASILMGLSNGIGTLAGI--IVPYALDGLIQANPTGCWTTVFTLAACVHLVG 504
            ||:||||.|||||:|.||||::||:|.:||:  ||   .:.|...||.| |..||.||..:.:.|
Worm   403 SGFNVNHFDIAPRHAPILMGIANGLGAIAGVGGIV---TNSLTYQNPDG-WQWVFLLAMSIDIFG 463

  Fly   505 CTFYGIFASGELQPWAEPPAEEQ 527
            ..|:.|||.|::.|||..|.:|:
Worm   464 IIFFLIFAKGDVLPWAREPEKEE 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	174/432 (40%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	159/392 (41%)
vglu-2	NP_499276.1	MFS	51..458	CDD:391944	170/418 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D144672at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030