DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGlut and Slc17a7

DIOPT Version :9

Sequence 1:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	XP_038966881.1	Gene:	Slc17a7 / 116638	RGDID:	620101	Length:	585	Species:	Rattus norvegicus

Alignment Length:	639	Identity:	275/639 - (43%)
Similarity:	353/639 - (55%)	Gaps:	118/639 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FKEKATGVFGGLKPNMEKFEISQSYHGGHGGYEEMEGGDREGRGPGGGHAYDDDDDRPDSPASFE 71
            |::.|....|.|...:||.:         .|.|.:| ...:|| |...|..|
  Rat     8 FRKLAGRALGRLHRLLEKRQ---------EGAETLE-LSADGR-PVTTHTRD------------- 48

  Fly    72 EIERPPLRKIDKYCKAECPC--MPARYTIATMACVGFMIAFGMRCNMSAAKLKGEHNGTVF---- 130
                ||:        .:|.|  :|.||.||.|:.:||.|:||:|||:..|.:...:|.|..
  Rat    49 ----PPV--------VDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGH 101

  Fly   131 --------------------------------MNWTVAVESHVDSSFFWGYLVTQIPGGFIASKF 163
                                            .||.......:..||||||:|||||||||..||
  Rat   102 VVVQTPYRSVHKQEAVTPTVGDIQGGDTEKAQFNWDPETVGLIHGSFFWGYIVTQIPGGFICQKF 166

  Fly   164 PANKIFGLSIVSSATLHLFVPFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSR 228
            .||::||.:||:::||::.:|.|..:.:| .||.||:||||.||||||||||||..||||:||||
  Rat   167 AANRVFGFAIVATSTLNMLIPSAARVHYG-CVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSR 230

  Fly   229 LATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPE 293
            |||.||.|||||.||.:||:|:|....|:.:.||.||.|||.||:||:.:.:|:|..||:||..|
  Rat   231 LATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEE 295

  Fly   294 LKYIEKSLGESAHPTMPSLK-TTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGF 357
            .||||.::||||....|..| .||||....||||||||||||||||.||||::.|.::.:..|||
  Rat   296 RKYIEDAIGESAKLMNPVTKFNTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGF 360

  Fly   358 KVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFNCGGFGMEGLFFLFVAHSST 422
            ::.:.|.|.:||||:||.|||.||.:||.||...|:||||||||.||||||||....|.|.:|.:
  Rat   361 EISKVGLVSALPHLVMTIIVPIGGQIADFLRSRHIMSTTNVRKLMNCGGFGMEATLLLVVGYSHS 425

  Fly   423 ATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPT 487
            ...|:..|...|.||||||||:|||||||||||||||||:|||:|||:|::.|..:..:.:....
  Rat   426 KGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTR 490

  Fly   488 GCWTTVFTLAACVHLVGCTFYGIFASGELQPWAEPPAEEQKVWAPPPGAITNTDPSQAGMLGDYM 552
            ..|..||.:|:.||..|..|||:|||||.||||||  ||.             ...:.|.:|...
  Rat   491 EEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEP--EEM-------------SEEKCGFVGHDQ 540

  Fly   553 KETSFGAPEYTEQSQMQQSTAISYGATGHVANNPFAMASGAPPIAEEDAPPTYG 606
            ...|       ::|:|:....                ..||||.    .||:||
  Rat   541 LAGS-------DESEMEDEVE----------------PPGAPPA----PPPSYG 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	228/450 (51%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	215/410 (52%)
Slc17a7	XP_038966881.1	MFS_SLC17A6_7_8_VGluT	66..515	CDD:340940	227/449 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342477
Domainoid	1	1.000	440	1.000	Domainoid score	I529
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1323
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D144672at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		otm46209
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X201
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910