Protein Alignment VGlut and SLC17A3

DIOPT Version :9

• Sequence 1: NP_001245848.1
• Gene: VGlut / 33427
• FlyBaseID: FBgn0031424
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_001091956.1
• Gene: SLC17A3 / 10786
• HGNCID: 10931
• Length: 498
• Species: Homo sapiens
• Alignment Length: 409
• Identity: 122/409 - (29%)
• Similarity: 211/409 - (51%)
• Gaps: 30/409 - (7%)

  Fly   132 NWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGHVVI 196
            :|:..::..:..:..:|.::|..|.|::|.:....::.|:|:.:::.|.|.:|.|...  |.|::
Human   106 DWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDF--GIVLL 168

  Fly   197 CV-RVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAP 260
            .| |::|||.:.........||..|.||.|||||.::|.||...|....:.:.|.:::.:|:...
Human   169 IVTRIVQGLSQSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFV 233

  Fly   261 FYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSL----GESAHPTMPSLKTTPWREMM 321
            ||.:|..|.:..:.|..:.:::|..:|.||..|.:||..||    |.|..|       .|.:.|:
Human   234 FYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIISSLKQQVGSSKQP-------LPIKAML 291

  Fly   322 RSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADH 386
            ||:|:::|.:..|...|....:|::..:::...:...:.:.|.:.:||.::...|...||.|||.
Human   292 RSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADF 356

  Fly   387 L--RKNGILSTTNVRKLFNCGGFGMEGLFFLFVAHSS----TATGAMFALTCGVAFSGFAISGYN 445
            |  :|..:::   |||:....|........:.:.:.:    ||| |:..|:||:  |....||..
Human   357 LLTKKFRLIT---VRKIATILGSLPSSALIVSLPYLNSGYITAT-ALLTLSCGL--STLCQSGIY 415

  Fly   446 VNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPTGCWTTVFTLAACVHLVGCTFYGI 510
            :|.|||||||:|.|||.|.|..::|.:|||.....|:..:|...|..||.|...|:|:|..||.|
Human   416 INVLDIAPRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLI 480

  Fly   511 FASGELQPWAEPPAEEQKV 529
            |...::|.|    |:|:|:
Human   481 FGEADVQEW----AKERKL 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	116/390 (30%)
		MFS_1	101..475	CDD:284993	102/353 (29%)
SLC17A3	NP_001091956.1	2A0114euk	23..497	CDD:129972	122/409 (30%)
		MFS	98..481	CDD:119392	115/389 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148728
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850