Protein Alignment VGlut and SLC17A4

DIOPT Version :9

• Sequence 1: NP_001245848.1
• Gene: VGlut / 33427
• FlyBaseID: FBgn0031424
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_005486.1
• Gene: SLC17A4 / 10050
• HGNCID: 10932
• Length: 497
• Species: Homo sapiens
• Alignment Length: 395
• Identity: 131/395 - (33%)
• Similarity: 200/395 - (50%)
• Gaps: 13/395 - (3%)

  Fly   132 NWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGHVVI 196
            :|:..::..:.||..:|..:..||.|::|..|.|..:.|..:..|:.|.||:|.|...... ::|
Human   104 DWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAGVA-LLI 167

  Fly   197 CVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPF 261
            .:|::||:.:.:.....:.||..||||:|||:|.|:|.|||..|..:.|...|||...:|:...|
Human   168 VLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVF 232

  Fly   262 YAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGESAHPTMPSLKTTPWREMMRSMPV 326
            |.:|..|......|..|.:::|..||.||..|.:||..||.:.......||   |.|.|::|:|:
Human   233 YIFGGIGCACCPLWFPLIYDDPVNHPFISAGEKRYIVCSLAQQDCSPGWSL---PIRAMIKSLPL 294

  Fly   327 YAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNG 391
            :||:|:.||..|.||.::.:..:::.......:.::|.:.:||.::....:..||:|||.|....
Human   295 WAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRK 359

  Fly   392 ILSTTNVRKLFNCGGFGMEGLFFLFV-----AHSSTATGAMFALTCGVAFSGFAISGYNVNHLDI 451
            ||....:||||...|.....:..:.:     :||.|.|    .|....|.|.|..||..||.|||
Human   360 ILRLITIRKLFTAIGVLFPSVILVSLPWVRSSHSMTMT----FLVLSSAISSFCESGALVNFLDI 420

  Fly   452 APRYASILMGLSNGIGTLAGIIVPYALDGLIQANPTGCWTTVFTLAACVHLVGCTFYGIFASGEL 516
            ||||...|.||......:||.|.|.|....|..:....|..||.|:|.|::.|..||.||...::
Human   421 APRYTGFLKGLLQVFAHIAGAISPTAAGFFISQDSEFGWRNVFLLSAAVNISGLVFYLIFGRADV 485

  Fly   517 QPWAE 521
            |.||:
Human   486 QDWAK 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	127/384 (33%)
		MFS_1	101..475	CDD:284993	114/347 (33%)
SLC17A4	NP_005486.1	UhpC	30..491	CDD:332119	131/395 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148636
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840