Protein Alignment VGlut and slc17a8

DIOPT Version :10

• Sequence 1: NP_608681.2
• Gene: VGlut / 33427
• FlyBaseID: FBgn0031424
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: XP_002936892.1
• Gene: slc17a8 / 100489470
• XenbaseID: XB-GENE-988965
• Length: 588
• Species: Xenopus tropicalis
• Alignment Length: 594
• Identity: 267/594 - (44%)
• Similarity: 358/594 - (60%)
• Gaps: 58/594 - (9%)

  Fly     2 KGLTAFKEKATGVFGGLKPNMEKFEISQSYHGGHGGYEEMEGGDREGRGPGGGHAYDDDDDRP-D 65
            :.|::||||   :|   .|..|  |:..|.....|..:.    ..:||.....:...|:|.|| .
 Frog     4 QALSSFKEK---IF---SPGKE--EVKNSIGDSLGNLQR----KIDGRNIEEDNIELDEDGRPVQ 56

  Fly    66 SPASFEEIERPPLRKIDKYCKAECPC-MPARYTIATMACVGFMIAFGMRCNMSAAKLKGEHNGTV 129
            :|.      :||.| .|.||     | :|.||.||.|:.:||.|:||:|||:..|.::..:|.||
 Frog    57 APT------QPPPR-FDCYC-----CGIPKRYIIAMMSGLGFCISFGIRCNLGVAIVEMVNNNTV 109

  Fly   130 FM-----------NWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFV 183
            ::           ||.......:..||||||::|||||||||:|..||::||.:|..::.|::.:
 Frog   110 YVDGKPEMQKAQFNWDPETVGLIHGSFFWGYIITQIPGGFIANKLAANRVFGAAIFLTSILNMLI 174

  Fly   184 PFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLS 248
            |.| ..:|...||.|||||||.||||||||||:|..||||:|||||||.:|.|||||.|:.:||:
 Frog   175 PSA-ARVHFGCVISVRVLQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVIAMPLA 238

  Fly   249 GLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGESAHPTMPSLK 313
            |:|...:|:.:.||.|||||:.||:||:....|:|..||:|:..|..|||.|:||.::.......
 Frog   239 GVLVQYIGWPSVFYIYGVFGMCWYVFWLLHATESPAAHPSITFEERTYIETSIGEGSNLVTTGKF 303

  Fly   314 TTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVP 378
            .|||::...||||||||||||||||.||||::.|.::.:..|||.:.:.|.:.::||::||.|||
 Frog   304 KTPWKKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFPISKVGLLSAVPHMVMTIIVP 368

  Fly   379 FGGMLADHLRKNGILSTTNVRKLFNCGGFGMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISG 443
            .||.|||.||...|||||.|||:.||||||||....|.|.:|.|...::..|...|.||||||||
 Frog   369 VGGQLADFLRSRKILSTTTVRKIMNCGGFGMEATLLLVVGYSHTKAISISFLVLAVGFSGFAISG 433

  Fly   444 YNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPTGCWTTVFTLAACVHLVGCTFY 508
            :|||||||||||||||||:|||:|||:|::.|..:..:.:......|..||.:||.||..|..||
 Frog   434 FNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKNKTREEWQNVFLIAAIVHYSGVIFY 498

  Fly   509 GIFASGELQPWAEPPA-EEQKVWAPPPGAITNTDPSQAGMLGDYMKETSFGAPEYTEQSQMQQST 572
            |||||||.|.||:|.: .|.|.     |.|.|.:.::         ||......:|..::..
 Frog   499 GIFASGEKQEWADPESLSEDKC-----GIIDNDELAE---------ETELNNESFTSSNKKS--- 546

  Fly   573 AISYGATGH 581
              |||:|.|
 Frog   547 --SYGSTIH 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_608681.2	MFS_SLC17A6_7_8_VGluT	99..512	CDD:340940	216/423 (51%)
slc17a8	XP_002936892.1	MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	216/423 (51%)