Protein Alignment VGlut and slc17a6b

DIOPT Version :10

• Sequence 1: NP_608681.2
• Gene: VGlut / 33427
• FlyBaseID: FBgn0031424
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_001122293.1
• Gene: slc17a6b / 100149756
• ZFINID: ZDB-GENE-030616-554
• Length: 584
• Species: Danio rerio
• Alignment Length: 614
• Identity: 279/614 - (45%)
• Similarity: 358/614 - (58%)
• Gaps: 73/614 - (11%)

  Fly    40 EMEGGDREG----RGPGGGHAYD--DDDDRPDSPASFEEIERPPLRKIDKYCKAECPC--MPARY 96
            |..|..:||    .|...||.|.  :...:|.......|..||......|....:|.|  :|.||
Zfish     6 EPAGFSKEGLKQLAGKTLGHVYRVIEKRQKPGENIELTEDGRPAQINERKAPLCDCTCFGLPRRY 70

  Fly    97 TIATMACVGFMIAFGMRCNMSAAKLKGEHNGTVFM------------NWTVAVESHVDSSFFWGY 149
            .||.|:.:||.|:||:|||:..|.:...:|.|:.:            ||.......:..||||||
Zfish    71 IIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTIHLNGKIIIKEKAKFNWDPETVGLIHGSFFWGY 135

  Fly   150 LVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGH--VVICVRVLQGLFEGVTYPA 212
            :|||||||:|:|:..||::||.:|:.::||::|:|.|   ..||  .||.||:||||.|||||||
Zfish   136 IVTQIPGGYISSRLAANRVFGAAILLTSTLNMFIPSA---ARGHYGCVIFVRILQGLVEGVTYPA 197

  Fly   213 CHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIW 277
            |||||..||||:|||||||.:|.|||||.|:.:||:|:|....|:.:.||.||.|||.||||||.
Zfish   198 CHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGCFGIFWYMFWIL 262

  Fly   278 LCFENPRKHPAISIPELKYIEKSLGESAHPTMPSLK-TTPWREMMRSMPVYAIIVANFCRSWNFY 341
            :.:|:|.:||.|:..|..|||:|:||||....|:.| .||||:...||||||||||||||||.||
Zfish   263 VSYESPAEHPTITAEERCYIEESIGESAKLLGPADKFKTPWRKFFTSMPVYAIIVANFCRSWTFY 327

  Fly   342 LLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFNCGG 406
            ||::.|.::.:..|||::.:.|.:.:||||:||.|||.||.||||||...|||||.|||:.||||
Zfish   328 LLLISQPAYFEEVFGFEISKVGMLSALPHLVMTIIVPIGGQLADHLRSKNILSTTTVRKIMNCGG 392

  Fly   407 FGMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAG 471
            ||||....|.|.:|.:...|:..|...|.||||||||:|||||||||||||||||:|||:|||:|
Zfish   393 FGMEATLLLIVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSG 457

  Fly   472 IIVPYALDGLIQANPTGCWTTVFTLAACVHLVGCTFYGIFASGELQPWAEPPAEEQKVWAPPPGA 536
            ::.|..:..:.:......|..||.:|:.||..|..|||||||||.||||:|..
Zfish   458 MVCPLIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGIFASGEKQPWADPEL------------ 510

  Fly   537 ITNTDPSQAGML--GDYMKET--------SFGAPEYTEQSQMQQSTAISYGATGHVANNPFAMAS 591
               |...:.|.:  .:..:||        :.|||            |.|||||..:..   ..|.
Zfish   511 ---TSDEKCGFIDEDELAEETGDITQSYGALGAP------------AKSYGATTQLNG---GWAE 557

  Fly   592 GAPPIAEEDAPPTY-GDVTNPGQYGYTQG 619
            |      .|....| .|....|.|||.||
Zfish   558 G------WDKREEYVQDGVEEGGYGYRQG 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGlut	NP_608681.2	MFS_SLC17A6_7_8_VGluT	99..512	CDD:340940	226/427 (53%)
slc17a6b	NP_001122293.1	MFS_SLC17A6_7_8_VGluT	73..498	CDD:340940	226/427 (53%)