DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-Wa and PIG-Wb

DIOPT Version :9

Sequence 1:	NP_608679.1	Gene:	PIG-Wa / 33425	FlyBaseID:	FBgn0031422	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_001261279.1	Gene:	PIG-Wb / 38220	FlyBaseID:	FBgn0035265	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	463	Identity:	189/463 - (40%)
Similarity:	274/463 - (59%)	Gaps:	27/463 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WRSIKESLDSFLTILPTILGFVLSRLLCGHLPMLSTRR--FLLELFLIGLPTVILITVGSAYSYT 83
            |.::.:|.:|.|.||.|:...:|:|::|..|.:..:..  :..|..|:.||.::|::|...||..
  Fly    45 WGTLVQSGESLLLILSTLWCILLARVVCQKLRLHGSADLCYATEFLLVILPCILLVSVAVDYSGY 109

  Fly    84 YSLVVSLAVLVYIYGNVAPNPPNFVYKV---GKRPIVFTLLRATAYSGTCAAILAVDFPSYPTDY 145
            ..|::.:|.|.::..:.|........:.   |.||:..::|||..:..|...|||:||.|:...|
  Fly   110 IGLLMLVATLWFLRTSRALERARTRVQFDLGGNRPMCLSILRALTHLITAVCILAIDFGSFYRPY 174

  Fly   146 RKSRTFGAAVMDMGIGLFVVTMGLVSHRARSITDLKKLRRSVI----PLLVLGLARTIVITLIDY 206
            ||||.|||.:||.||||||.||.:||.|.|..:|   ||||||    ||::||||||:.|..:.|
  Fly   175 RKSRQFGAKLMDTGIGLFVFTMAMVSRRTRHWSD---LRRSVIYSALPLILLGLARTVSILTLSY 236

  Fly   207 HQDETEYGRHLNAFFILGFTKLLGSCYSLLVNSDEQLLALAIGLLFLHEVVLQ-LGLSEFVMS-S 269
            .||..|||:||||||.|||||.|||..|:|...|..||.|..|||.:|:..|. ||:|::||: .
  Fly   237 GQDAHEYGQHLNAFFTLGFTKFLGSLVSILARKDLHLLPLGFGLLVIHQFGLSVLGISDYVMNED 301

  Fly   270 APHEGFFSANREGLSSLHGCVALYLLSIYFAKWYTSRDSLTYQGLIRKLKSILFVAILCWKLVFI 334
            .....|.:||||||.||.|.|.|:|||||..:|..::..|||...:|||:.:.::.::.|....|
  Fly   302 VERSSFLNANREGLVSLPGFVGLFLLSIYVNRWMVAKSLLTYSEFVRKLRRLFYLVLILWTSFVI 366

  Fly   335 SSFLTGIARVTFSFGYVIWIFAV-SLSLIVIY-AFFFELKLVRP-----------DICSKKSIRD 386
            |::..||:|||.:.|||||:.|: |.:|...: |..|.:..|.|           .:.|.:::..
  Fly   367 SAYEIGISRVTCNLGYVIWMLAIGSTTLCASFGAIDFAINSVMPWDPNPWEDHEKGLLSGEAVVK 431

  Fly   387 DGQKNISLPTFVESLNMNGLTHFMISNFLTGMVNMSLNPGHRSDLESVVILSIYMFVCAGVVFLM 451
            ....::...|..::||.||||.|:::|.||||||:.|.|..||..|||:||.:|||:...:|..:
  Fly   432 KRGGSVVPFTISQALNKNGLTFFLVANILTGMVNIFLRPEDRSHSESVIILLVYMFLATKLVHEL 496

  Fly   452 LKKGIRVA 459
            ||:|||:|
  Fly   497 LKRGIRLA 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-Wa	NP_608679.1	GWT1	59..457	CDD:295177	175/419 (42%)
PIG-Wb	NP_001261279.1	GWT1	85..503	CDD:295177	176/420 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446170
Domainoid	1	1.000	101	1.000	Domainoid score	I2333
eggNOG	1	0.900	-	-		E1_COG5062
Homologene	1	1.000	-	-		H6243
Inparanoid	1	1.050	160	1.000	Inparanoid score	I1640
Isobase	1	0.950	-	0	Normalized mean entropy	S2630
OMA	1	1.010	-	-		QHG55384
OrthoDB	1	1.010	-	-		D1202772at2759
OrthoFinder	1	1.000	-	-		FOG0003627
OrthoInspector	1	1.000	-	-		otm26582
orthoMCL	1	0.900	-	-		OOG6_103051
Panther	1	1.100	-	-	P	PTHR20661
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2503
	14	13.760