DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eogt and eogt

DIOPT Version :9

Sequence 1:	NP_001259934.1	Gene:	Eogt / 33424	FlyBaseID:	FBgn0264672	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001072691.1	Gene:	eogt / 780148	XenbaseID:	XB-GENE-994619	Length:	525	Species:	Xenopus tropicalis

Alignment Length:	545	Identity:	243/545 - (44%)
Similarity:	326/545 - (59%)	Gaps:	53/545 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPILIGILHLSLAE--DAKHLDGFSLP------SLPSEHLIRYLNTFPKL------------KQQ 48
            |.:|..::|.|...  |:...:|.:|.      .||.:|:..||::...:            ||.
Frog     6 LLLLFHVIHFSHGNEIDSAASNGSALSYHYGKLYLPDDHIPYYLHSNRHIAALCRRDPHCPFKQH 70

  Fly    49 LPTNLTGKGTISSACWGHERDCTPAGRFQTPQCPGEHTGWARSKEAQVRTFYNQADFGYIQEQLS 113
            | .||       ::|||:|:.||....:..|.|.....|||::.|.....|:.||||||::|:|:
Frog    71 L-QNL-------NSCWGYEKSCTKGHGYSYPVCDQVDFGWAKTIEESQEVFWKQADFGYVKERLA 127

  Fly   114 QLTPQCVPTYLGDSSLECTHYLRFCRGRNLLFDFRGLEQREERIRYHMDVLGPGQLLGHCKLNRT 178
            :....|.|...|||.|.|:..|:.||..||..|.|...:.:|  .:..|.|..|::.|.|.|::.
Frog   128 ETQILCRPQEQGDSMLACSRNLQHCRATNLYLDLRNPRRGQE--NFKEDFLQEGEIGGRCNLDKQ 190

  Fly   179 RLSGEMEHIG---SALQSWGPELRNFDVLPHPVLESGLCDVVVNTPTFIMKIDATYNMYHHFCDF 240
            .|..:    |   |.||||..||:::..|....:|...||::::.||:.||:||..|||||||||
Frog   191 ALLSQ----GAWKSPLQSWFAELQSYSSLTFKPVEDAHCDIIIDKPTYFMKLDAGVNMYHHFCDF 251

  Fly   241 FNLYASLFVNQSHPAAFNTDVQILIWET--YPYDSPFRDTFKAFSQRPVWTLSDVEGKRVCFKNV 303
            .|||.:..||.|    |:||:.|::|.|  |.|...|.||:|||:...:..|...:.||||||:.
Frog   252 VNLYITQHVNNS----FSTDINIVMWTTSVYGYGDLFSDTWKAFTDYDITHLKAYDNKRVCFKDA 312

  Fly   304 VLPLLPRMIFGLFYNTPIIQGCSNSGLFRAFSEFILHRLQIPYK-PPQQKIRITYLSRRTKYRQV 367
            |..|||||.:|||||||:|..|..||||||||:.:||||.|..: |.:.|||||.|.|.|::|::
Frog   313 VFALLPRMRYGLFYNTPLISNCHGSGLFRAFSQHVLHRLNITQQLPKEAKIRITILVRSTEFRKI 377

  Fly   368 LNEDELLAPLEANDKYDVQRVSYER--LPFTNQLAITRNTDILIGMHGAGLTHLLFLPNWACIFE 430
            ||.|||:..|||...:.|:.|.|:.  |.|..||.||.|:||.|||||||||||||||:||.:||
Frog   378 LNLDELVHALEAEPTFQVKVVDYKYRVLGFLEQLEITHNSDIFIGMHGAGLTHLLFLPDWAVVFE 442

  Fly   431 LYNCEDPNCYKDLARLRGVRYRTWEQRDLVYPQDEGHHPEGGAHAKFTNYSFDVKEFVHLVDGAA 495
            ||||||..||.|||||||:||.|||.||.|:|||:||||..|.|.|||||:|||:||:.||..||
Frog   443 LYNCEDERCYLDLARLRGIRYMTWENRDKVFPQDKGHHPNLGEHPKFTNYAFDVEEFLRLVRQAA 507

  Fly   496 EEILSHKEFPRRASENPSKTQRNEL 520
            :.:..|.::|.|.:       |:||
Frog   508 KNVSRHSKWPFRRT-------RDEL 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eogt	NP_001259934.1	DUF563	232..454	CDD:282442	130/226 (58%)
eogt	NP_001072691.1	DUF563	243..470	CDD:398330	133/230 (58%)
		Required for optimal activity. /evidence=ECO:0000250	293..295		0/1 (0%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	522..525		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	263	1.000	Domainoid score	I1898
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H65276
Inparanoid	1	1.050	442	1.000	Inparanoid score	I1610
OMA	1	1.010	-	-		QHG48941
OrthoDB	1	1.010	-	-		D339032at33208
OrthoFinder	1	1.000	-	-		FOG0005569
OrthoInspector	1	1.000	-	-		oto102394
Panther	1	1.100	-	-	LDO	PTHR20961
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3027
SonicParanoid	1	1.000	-	-		X1388
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110