DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eogt and EOGT

DIOPT Version :9

Sequence 1:	NP_001259934.1	Gene:	Eogt / 33424	FlyBaseID:	FBgn0264672	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_011531901.1	Gene:	EOGT / 285203	HGNCID:	28526	Length:	545	Species:	Homo sapiens

Alignment Length:	518	Identity:	234/518 - (45%)
Similarity:	307/518 - (59%)	Gaps:	64/518 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LPSEH-------------------LIRYLNTFPKLKQQLPTNLTGKGTISSACWGHERDCTPAGR 75
            ||.||                   |..|.....|||.               |||:|:.|.|..|
Human    42 LPEEHIPFFLHNNRHIATVCRKDSLCPYKKHLEKLKY---------------CWGYEKSCKPEFR 91

  Fly    76 FQTPQCPGEHTGWARSKEAQVRTFYNQADFGYIQEQLSQLTPQCVPTYLGDSSLECTHYLRFCRG 140
            |..|.|.....||..:.|:....|:.||||||.:|:|.::...|.|....||||.|:.||::||.
Human    92 FGYPVCSYVDMGWTDTLESAEDIFWKQADFGYARERLEEMHVLCQPKETSDSSLVCSRYLQYCRA 156

  Fly   141 RNLLFDFRGLEQREERIRYHMDVLGPGQLLGHCKLNRTRLSGEMEHIGSALQSWGPELRNFDVLP 205
            .||..|.|.:::..:  |:..|....|::.|||||:...|:.|.:. .|.||||..||:::..|.
Human   157 TNLYLDLRNIKRNHD--RFKEDFFQSGEIGGHCKLDIRTLTSEGQR-KSPLQSWFAELQSYTQLN 218

  Fly   206 HPVLESGLCDVVVNTPTFIMKIDATYNMYHHFCDFFNLYASLFVNQSHPAAFNTDVQILIWET-- 268
            ...:|...||:|:..||:.||:||..|||||||||.|||.:..||.|    |:|||.|::|:|
Human   219 FRPIEDAKCDIVIEKPTYFMKLDAGVNMYHHFCDFINLYITQHVNNS----FSTDVYIVMWDTKC 279

  Fly   269 ------------------YPYDSPFRDTFKAFSQRPVWTLSDVEGKRVCFKNVVLPLLPRMIFGL 315
                              |.|...|.||:.||:...|..|...:.||||||..|..|||||.:||
Human   280 LSPPAMVLRPPQPCGTSSYGYGDLFSDTWNAFTDYDVIHLKTYDSKRVCFKEAVFSLLPRMRYGL 344

  Fly   316 FYNTPIIQGCSNSGLFRAFSEFILHRLQIPYKPPQQ-KIRITYLSRRTKYRQVLNEDELLAPLEA 379
            |||||:|.||.|:||||||::.:||||.|..:.|:. |||:|.|:|.|:||::||::||:..|:.
Human   345 FYNTPLISGCQNTGLFRAFAQHVLHRLNITQEGPKDGKIRVTILARSTEYRKILNQNELVNALKT 409

  Fly   380 NDKYDVQRVSYE--RLPFTNQLAITRNTDILIGMHGAGLTHLLFLPNWACIFELYNCEDPNCYKD 442
            ...::||.|.|:  .|.|.:||.||.||||.|||||||||||||||:||.:||||||||..||.|
Human   410 VSTFEVQIVDYKYRELGFLDQLRITHNTDIFIGMHGAGLTHLLFLPDWAAVFELYNCEDERCYLD 474

  Fly   443 LARLRGVRYRTWEQRDLVYPQDEGHHPEGGAHAKFTNYSFDVKEFVHLVDGAAEEILSHKEFP 505
            |||||||.|.||.:::.|:|||:||||..|.|.|||||||||:||::||..||:.:|.|.::|
Human   475 LARLRGVHYITWRRQNKVFPQDKGHHPTLGEHPKFTNYSFDVEEFMYLVLQAADHVLQHPKWP 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eogt	NP_001259934.1	DUF563	232..454	CDD:282442	130/244 (53%)
EOGT	XP_011531901.1	DUF563	<344..490	CDD:282442	88/145 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159729
Domainoid	1	1.000	265	1.000	Domainoid score	I1920
eggNOG	1	0.900	-	-		E1_KOG4698
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H65276
Inparanoid	1	1.050	453	1.000	Inparanoid score	I1603
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48941
OrthoDB	1	1.010	-	-		D339032at33208
OrthoFinder	1	1.000	-	-		FOG0005569
OrthoInspector	1	1.000	-	-		oto88517
orthoMCL	1	0.900	-	-		OOG6_105989
Panther	1	1.100	-	-	LDO	PTHR20961
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3027
SonicParanoid	1	1.000	-	-		X1388
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800