DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atxn7 and Atxn7l1

DIOPT Version :9

Sequence 1:	NP_001259932.1	Gene:	Atxn7 / 33423	FlyBaseID:	FBgn0031420	Length:	971	Species:	Drosophila melanogaster
Sequence 2:	XP_038969089.1	Gene:	Atxn7l1 / 362726	RGDID:	1305730	Length:	994	Species:	Rattus norvegicus

Alignment Length:	1095	Identity:	198/1095 - (18%)
Similarity:	352/1095 - (32%)	Gaps:	331/1095 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PDSSAGSNSGSG---SAGLSLFSLQ----------GQKWQQVFDMEKVIKQLRTAEKTYLRGGKN 80
            |..||.:..|:|   ..|.::.:|.          |:.|....|..|    |..::...|
  Rat     9 PCLSAAAAEGTGKKQQEGTAMATLHRKVPSPEAFLGKPWSSWIDAAK----LHCSDNVDL----- 64

  Fly    81 SSAGADQQAKVQVQRLQSADMAYYDLAPKLASRDIVLCSSCSGCYTKAGFQHHIALQHPSVWEAT 145
            ..||.:.....:|.||...||..:...|......:|:||:|:.......||.|...:|
  Rat    65 EEAGKEGGKSREVMRLNKEDMHLFGHYPAHDDFYLVVCSACNQVVKPQVFQSHCERRH------- 122

  Fly   146 SSKVNPNPNGTAISSDSRLTATEISQEGGAIVPSSPTDTLSASTLSSCSNGSSSSASLQHPAAAG 210
            ||...|:|:..|..:.:..|                  :|:.:...:|.:|        |.|.
  Rat   123 SSMCRPSPSPAASPASNLRT------------------SLAQAKTKACVSG--------HNAV-- 159

  Fly   211 SSSTTSSSSSSRHKSSSSKSSSSSSSKGSSSTSAGSRSRSKSS-KNRHHSSPAPALLESNHKESK 274
                  ||:|...|:......:|||::.:..::.|.|.:.... :..|...|.....:..|.:|:
  Rat   160 ------SSTSKPFKTPKDNLLTSSSTQHTVFSAKGPRDKPWCCVREEHIEGPRGGWNQRIHGDSR 218

  Fly   275 GSKKSSAIAAPPVVAAVVKEEPPSVGAAPAAITMFSSSSNSSCSLPP--TPTLGAAS-------- 329
            .......:.:...:..:||.:..:|.......|..:|||:|:.|.||  .|||.:.|
  Rat   219 PGSVPVPVVSLEKIPNLVKADGANVKMNSTTTTAATSSSSSAVSTPPLIKPTLMSKSVPPSPEKT 283

  Fly   330 -----------------------------SEVAMGVNYSPAQLQTDAE---------KLPELQPK 356
                                         ||.....|.....|..:.:         |...|..:
  Rat   284 LNGKGTLSATIDKKHPNGTKNSNKPYRRLSEREFDPNKHCGVLDPETKKPCTRSLTCKTHSLSHR 348

  Fly   357 KKLKGS--------SDHRIKAEKEKNKDKSLVNSYEQQQVL----SELDQAVSSITGAVSAE-QV 408
            :.:.|.        ::|:.|:.:::.|:..|.::   :::|    ..:..|:...:|:..|| :|
  Rat   349 RAVPGRKKQFDLLLAEHKAKSREKEVKEHLLTSA---REILPNPPGPVPDALQGSSGSTVAEPKV 410

  Fly   409 APDEEELP----LPNTSDENSISQTLDEM----------------LDSKLINEILNNFDESALDT 453
            |...:..|    ||..|..||||.:....                |.|:|      :.||..:|.
  Rat   411 ASPPKSRPLNSVLPRPSSANSISSSASSNHSGYTPEPPLPPAGGDLASRL------SSDEGEMDG 469

  Fly   454 SQQQSQQQAQNGSLSHPAQATKRLRFEDGTIGEDYAVYQQQAVQQVYGEEEHQQELTTIDAMQLQ 518
            :.:..:...| .|..|| :......|....:|..|.|:.:                      :..
  Rat   470 ADESEKLDCQ-FSTHHP-RPLAFCSFGSRLMGRGYYVFDR----------------------RWD 510

  Fly   519 QLIYQQQQMLEQQQLQEQQQQQQQDQKLQDHEQQRQFSVYNVPSLTD--EAMVNPQQQQLEEHMI 581
            :..:....|:|:....:..:.:....:........:..:.|:.||::  .|.|
  Rat   511 RFRFALNSMVEKHLNSQMWKHRSPSHRASGPSPLFRTCLTNLLSLSNIGAAWV------------ 563

  Fly   582 LPSIIYEITESNPVSMLEQKVLAEFLTNAGYENVDV-NVVQSGGIQTNLSSGTEANQLADELADF 645
              |.:..:....|:::..|        ..|.|..:. .:...||::       :..:..:....|
  Rat   564 --STLESVAPRCPLNLAAQ--------TPGPEGPEPGGMAADGGME-------DIRKKRNGQDSF 611

  Fly   646 EFSKLETV-SDTVKTVKLEAK----AASQP------------------PTTNPQINHHPSLANAK 687
            .|:|..|: .:|.....|.|:    ||..|                  |.:||...:.||...:.
  Rat   612 FFNKHLTLHQETPTQYSLSARKIPPAADSPMPSPAAHITTPVPASVLQPFSNPSAVYLPSAPISS 676

  Fly   688 YHEDSYF--NVMLYSGA------PRPLAMNTFGMVKLPQGLGV---TFRKNLLTTRKANNNLLSL 741
            ....||.  :.||...|      ||.|..:|.....:...|.:   ||:
  Rat   677 RLTSSYIMTSAMLSDAAFVASPDPRVLMSHTTAFPHVAATLSIMDSTFK---------------- 725

  Fly   742 SGGNHLGVVGQLARTPPPPSPALSNGLPGKNPASGRTIYAQRSNV----IAQDRLRCNKRALVGG 802
                        |.:...|.||:   :|..:....:|..::.|.|    ...|....||:
  Rat   726 ------------APSAVSPIPAV---IPSPSHKPSKTKTSKSSKVKDLSARSDESPSNKK----- 770

  Fly   803 KAGGGSSGSPGVMTAKRLNELLMGKAKK-------------EEKPPPDS-----EDGGEQPTKDK 849
            :....|..|..:.....|:..|.|..||             :..||.:|     .:.|..|...|
  Rat   771 RKPQSSISSSSLSLQASLSSPLSGPHKKNCVLNASSALNSYQAAPPYNSLSVHNSNNGVSPLSAK 835

  Fly   850 ERDKEEDNKLTFSFYEKRRRLLAGKLE---QLQPLGRPSFTLPLQ-------------SNHNASQ 898
            ...            ..|..|.:|.::   |:..:|..|.:.||.             ::|||..
  Rat   836 LEP------------SGRTSLPSGPMDIVRQVGAVGGSSGSCPLSVSSLALHAGDLSLASHNAVS 888

  Fly   899 SQSHSPQQLLKKQLLRTLSDSSSNMNISNMNNISNLNSSNTPSANSNPPWKGNSS 953
            |...|..:...|: .:..|.||....|:.|..:::::..|.||..:..|...||:
  Rat   889 SLPLSFDKSEGKK-RKNSSPSSKACKITKMPGMNSVHKKNPPSLLAPVPDPVNSA 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atxn7	NP_001259932.1	None
Atxn7l1	XP_038969089.1	SCA7	309..369	CDD:400555	8/59 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4140
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900