DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atxn7 and ATXN7L1

DIOPT Version :9

Sequence 1:	NP_001259932.1	Gene:	Atxn7 / 33423	FlyBaseID:	FBgn0031420	Length:	971	Species:	Drosophila melanogaster
Sequence 2:	NP_001372525.1	Gene:	ATXN7L1 / 222255	HGNCID:	22210	Length:	862	Species:	Homo sapiens

Alignment Length:	1050	Identity:	193/1050 - (18%)
Similarity:	327/1050 - (31%)	Gaps:	346/1050 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PDSSAGSNSGSG---SAGLSLFSLQ----------GQKWQQVFDMEKVIKQLRTAEKTYLRGGKN 80
            |..||.:..|:|   ..|.::.:|.          |:.|....|..|    |..::...|
Human     9 PCLSAAAAEGTGKKQQEGRAMATLDRKVPSPEAFLGKPWSSWIDAAK----LHCSDNVDL----- 64

  Fly    81 SSAGADQQAKVQVQRLQSADMAYYDLAPKLASRDIVLCSSCSGCYTKAGFQHHIALQHPSVWEAT 145
            ..||.:.....:|.||...||..:...|......:|:||:|:.......||.|...:|.|:...:
Human    65 EEAGKEGGKSREVMRLNKEDMHLFGHYPAHDDFYLVVCSACNQVVKPQVFQSHCERRHGSMCRPS 129

  Fly   146 SSKVNPNPNGTAISSDSRLTATEISQEGGAIVPSSPTDTLSASTLSSCSNGSSSSASLQHPAAAG 210
            .|.|:|                          .|:|..:|......:|.:|..|::|...|....
Human   130 PSPVSP--------------------------ASNPRTSLVQVKTKACLSGHHSASSTSKPFKTP 168

  Fly   211 SSSTTSSSSSSRHKSSSSKSSSSSSSKGS-----------SSTSAGSRSRSKSSKNRHHSSPAPA 264
            ..:..         :||||..:...:|||           |.....:..::..:..:.:|:...|
Human   169 KDNLL---------TSSSKQHTVFPAKGSRDKPCVPVPVVSLEKIPNLVKADGANVKMNSTTTTA 224

  Fly   265 LLESNHKESKGSKKSSAIAAPPVVAAVV--KEEPPS-------VGAAPAAITMFSSSSNSSCSLP 320
            :       |..|..|||::.||::..|:  |..|||       .|..|..|.....:...:.:.|
Human   225 V-------SASSTSSSAVSTPPLIKPVLMSKSVPPSPEKILNGKGILPTTIDKKHQNGTKNSNKP 282

  Fly   321 ----------PTPTLGAASSEVAMGVNYSPAQLQTDAEKLPELQPKKKLKGS--------SDHRI 367
                      |....|....|..     .|....... |...|..::.:.|.        ::|:.
Human   283 YRRLSEREFDPNKHCGVLDPETK-----KPCTRSLTC-KTHSLSHRRAVPGRKKQFDLLLAEHKA 341

  Fly   368 KAEKEKNKDKSLVNSYEQQQVLSELDQAVSSITGAVSAE----QVAPDEEELP----LPNTSDEN 424
            |:.:::.|||..:.:..::.:.|:...|..|:.|:..:.    :||...:..|    ||..|..|
Human   342 KSREKEVKDKEHLLTSTREILPSQSGPAQDSLLGSSGSSGPEPKVASPAKSRPPNSVLPRPSSAN 406

  Fly   425 SISQTLDEM----------------LDSKLINEILNNFDESALDTSQQQSQQQAQNGSLSHPAQA 473
            |||.:....                |.|:|      :.||..:|.:.:..:...| .|..|| :.
Human   407 SISSSTSSNHSGHTPEPPLPPVGGDLASRL------SSDEGEMDGADESEKLDCQ-FSTHHP-RP 463

  Fly   474 TKRLRFEDGTIGEDYAVYQQQAVQQVYGEEEHQQELTTIDAMQLQQLIYQQQQMLEQQQLQEQQQ 538
            .....|....:|..|.|:.:                      :..:..:....|:| :.|..|..
Human   464 LAFCSFGSRLMGRGYYVFDR----------------------RWDRFRFALNSMVE-KHLNSQMW 505

  Fly   539 QQQQDQKLQDHEQQRQFSVYNVPSLTDEAMVNPQQQQLEEHMILPSIIYEITESNPVSMLEQKVL 603
            ::                   :|...|..              |||....||...|.|:|:.
Human   506 KK-------------------IPPAADSP--------------LPSPAAHITTPVPASVLQP--- 534

  Fly   604 AEFLTNAGYENVDVNVVQSGGIQTNLSSGTEANQLADELADFEFSKLETVSDTVKTVKLEAKAAS 668
                    :.|.....:.|..|.:.|:                       |..:.|..:.:.||.
Human   535 --------FSNPSAVYLPSAPISSRLT-----------------------SSYIMTSAMLSNAAF 568

  Fly   669 QPPTTNPQINHHPSLANAKYHEDSYFNVMLYSGAPRPLAMNTFGMVKLPQGLGVTFRKNLLTTRK 733
               .|:|..:...|...|..|..:..::|          .:||   |.|..:.
Human   569 ---VTSPDPSALMSHTTAFPHVAATLSIM----------DSTF---KAPSAVS------------ 605

  Fly   734 ANNNLLSLSGGNHLGVVGQLARTPPPPSPALSNGLPGKNPASGRTIYAQRSNV----IAQDRLRC 794
                                      |.||:   :|..:....:|..::.|.|    ...|....
Human   606 --------------------------PIPAV---IPSPSHKPSKTKTSKSSKVKDLSTRSDESPS 641

  Fly   795 N-KRALVGGKAGGGSSGSPGVMTAKRLNELLMGKAKK-------------EEKPPPDS-----ED 840
            | ||......:...||.|..:.|:  |:..|.|..||             :..||.:|     .:
Human   642 NKKRKPQSSTSSSSSSSSSSLQTS--LSSPLSGPHKKNCVLNASSALNSYQAAPPYNSLSVHNSN 704

  Fly   841 GGEQPTKDKERDKEEDNKLTFSFYEKRRRLLAGK----LEQLQPLGRPSFTLPLQ---------- 891
            .|..|             |:.......|..|.|.    :.|:..:|..|.:.||.
Human   705 NGVSP-------------LSAKLEPSGRTSLPGGPADIVRQVGAVGGSSDSCPLSVPSLALHAGD 756

  Fly   892 ---SNHNASQSQSHSPQQLLKKQLLRTLSDSSSNMNISNMNNISNLNSSNTPSANSNPPWKGNSS 953
               ::|||..|...|..:...|: .:..|.||....|:.|..:::::..|.||..:..|...||:
Human   757 LSLASHNAVSSLPLSFDKSEGKK-RKNSSSSSKACKITKMPGMNSVHKKNPPSLLAPVPDPVNST 820

  Fly   954 NP---GGNST 960
            :.   |.||:
Human   821 SSRQVGKNSS 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atxn7	NP_001259932.1	None
ATXN7L1	NP_001372525.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..189		10/43 (23%)
		SCA7	283..343	CDD:400555	8/65 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..448		24/111 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..673		17/71 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4140
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900