DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3597 and dhdh

DIOPT Version :9

Sequence 1:	NP_001259930.1	Gene:	CG3597 / 33420	FlyBaseID:	FBgn0031417	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_001120637.1	Gene:	dhdh / 100145807	XenbaseID:	XB-GENE-5788276	Length:	334	Species:	Xenopus tropicalis

Alignment Length:	329	Identity:	129/329 - (39%)
Similarity:	188/329 - (57%)	Gaps:	6/329 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WGIAAAGRITQDFVTALGTVEKSRHVVVAVADVDGQRAQQFAQRNQIPRHYDGFDALALDREVEV 73
            |||.:.|:|:.||:.||.|:....|.|||||..|.::|:.|||..:||:.|..::.||.|..::|
Frog     5 WGICSTGKISNDFLVALETLPAQDHQVVAVAARDLKQARDFAQIRKIPKAYGSYEELAKDPNIDV 69

  Fly    74 VYVGTLNPFHYAVVHLMLARGKNVLCETPMCLSVEQAKELYTLAEQRGVFLMEGNSMWSRFFPSY 138
            :|||.|:..|..||.:.|...||||||.|:.::..:.:||.:.|....||.||  ::||||||.|
Frog    70 IYVGVLHTVHRDVVLMFLQNKKNVLCEKPLAMNSAEVQELTSAARAYNVFFME--ALWSRFFPVY 132

  Fly   139 DRLRELLKNDVIGEVTQVKVQHGFRLAHMERVCNRSLGGSILMDIGIYALQLGQFVF-GVSPVKI 202
            :::|.||..:.||:|..|:.:.|....|:.|...:.|||..|:|||.|.:|....|| |..|..:
Frog   133 EQIRTLLSQNAIGDVKVVRAEFGSNQHHVPRAVQKELGGGALLDIGCYCIQFALMVFNGEKPESV 197

  Fly   203 LPSGTQLNKERVDVQIDFMLDYGDGRRLVALVTGLENLENDAVITGTKGEIKL-SNYWCCTQISR 266
            ...|. |....||..:..:|.|...|:.:...|.:..:.|.|.|.|:||.|:: |..||.|.:.
Frog   198 TAKGF-LYDTGVDETVTIILQYPGKRQAILTCTIMAAMPNQAAICGSKGMIQVPSCMWCPTSVI- 260

  Fly   267 SNAPPESWPLPRAKFDFHYTNTCGLRYEAEEVRRCIEKRLLESPKFTHAESLELAAIADEIRRQI 331
            .|.....:|||.:....|:||:.||.||||.||:|:.|.|.|||.....:|..|::|.||:|.|:
Frog   261 VNGKETKFPLPHSTKPMHFTNSTGLSYEAEHVRQCLLKGLKESPIMRLKDSELLSSIMDEVRGQL 325

  Fly   332 GVVY 335
            ||.:
Frog   326 GVKF 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3597	NP_001259930.1	MviM	7..332	CDD:223745	127/324 (39%)
		GFO_IDH_MocA	7..127	CDD:279716	49/117 (42%)
		GFO_IDH_MocA_C	142..228	CDD:304482	29/86 (34%)
dhdh	NP_001120637.1	MviM	1..302	CDD:223745	117/300 (39%)
		GFO_IDH_MocA	4..121	CDD:279716	48/115 (42%)
		GFO_IDH_MocA_C	136..>201	CDD:304482	23/64 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4889
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57478
OrthoDB	1	1.010	-	-		D351032at33208
OrthoFinder	1	1.000	-	-		FOG0001373
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22604
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1924
SonicParanoid	1	1.000	-	-		X868
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.060