DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axud1 and CSRNP3

DIOPT Version :9

Sequence 1:	NP_001259928.1	Gene:	Axud1 / 33419	FlyBaseID:	FBgn0261647	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	XP_024308922.1	Gene:	CSRNP3 / 80034	HGNCID:	30729	Length:	632	Species:	Homo sapiens

Alignment Length:	579	Identity:	173/579 - (29%)
Similarity:	258/579 - (44%)	Gaps:	145/579 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 LKRRLED-------------------SES-DAIDLV-PDMSA--PPVAPQKRTKR----SINFDE 308
            |||:.|:                   ||| |:.|.| |..|:  .|.:..||.||    :::|..
Human    52 LKRKFEEVDGSSPCSSVRESDDEVSSSESADSGDSVNPSTSSHFTPSSILKREKRLRTKNVHFSC 116

  Fly   309 VKVFYFPRQQGFSCVPTAGGCTLGMGARHVGFKTMTLAEHAAELRRAHRSQNQE----------- 362
            |.|:||.|:|||:.||:.||.||||.:||...:..||.|.|.|..|.||...:|
Human   117 VTVYYFTRRQGFTSVPSQGGSTLGMSSRHNSVRQYTLGEFAREQERLHREMLREHLREEKLNSLK 181

  Fly   363 LQPRGSSSDDSEESEEDYLSEGSGSD-----AEDGSNGFLQPVTPKQRRALLKAAGVRKIDASEK 422
            |:...:.:.:|||:....|.:.|..|     .|.....||||:..|:|||||:|:||:|||..||
Human   182 LKMTKNGTVESEEASTLTLDDISDDDIDLDNTEVDEYFFLQPLPTKKRRALLRASGVKKIDVEEK 246

  Fly   423 SECRDIRNSREVCGCSCREFCDPETCACSQAGIKCQVDRAMFPCGCTREACGNTVGRVEFNPTRV 487
            .|.|.||.|||.|||.||.||||:||.||.|||||||||..||||||:|.|.||.||:||||.||
Human   247 HELRAIRLSREDCGCDCRVFCDPDTCTCSLAGIKCQVDRMSFPCGCTKEGCSNTAGRIEFNPIRV 311

  Fly   488 RTHYIHTVMRLDLEQ-RQGSVQGVQGGHLQPQQQQPSQQTIGYS---------PVGTAGSTSAYF 542
            |||::||:|:|:||: |:..:..:.|.|.:......|...:.:|         .:.|....:...
Human   312 RTHFLHTIMKLELEKNREQQIPTLNGCHSEISAHSSSMGPVAHSVEYSIADSFEIETEPQAAVLH 376

  Fly   543 LQTQ----------------SNYSSGYA-------SPAYTPESSVSYYQQQVQQ----------- 573
            ||:.                |::.||..       :|:.:.|......:::.::
Human   377 LQSAEELDCQGEEEEEEEDGSSFCSGVTDSSTQSLAPSESDEEEEEEEEEEEEEDDDDDKGDGFV 441

  Fly   574 PGVPTAGQLIP-------------QQQQAQSQSYAGYAQLDSL----DSGLFASGSNATPSYGEL 621
            .|:.|..:::|             .:..|::.|:  ||...:|    ||.:..:.:..:.:|.|
Human   442 EGLGTHAEVVPLPSVLCYSDGTAVHESHAKNASF--YANSSTLYYQIDSHIPGTPNQISENYSE- 503

  Fly   622 YQSLSYGSTQITSYTAAYQQH-----------------SASPAVAVA-------PGAPSSCAY-- 660
            ..::..|:..:..||...:|.                 :|:|:|.|.       .|.|.:..|
Human   504 RDTVKNGTLSLVPYTMTPEQFVDYARQAEEAYGASHYPAANPSVIVCCSSSENDSGVPCNSLYPE 568

  Fly   661 -----------SSCAVPSVPPYGNATTTASSNVPYQTTAVSMTAASTSASPSRLVGNPV 708
                       |....||...:.:| ....|::.......|::.|..|......:.:||
Human   569 HRSNHPQVEFHSYLKGPSQEGFVSA-LNGDSHISEHPAENSLSLAEKSILHEECIKSPV 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axud1	NP_001259928.1	CSRNP_N	301..500	CDD:292638	110/218 (50%)
Axud1	NP_001259928.1	PHA03255	643..>786	CDD:165513	17/86 (20%)
CSRNP3	XP_024308922.1	CSRNP_N	110..324	CDD:318276	108/213 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160220
Domainoid	1	1.000	218	1.000	Domainoid score	I2657
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001585
OrthoInspector	1	1.000	-	-		otm40615
orthoMCL	1	0.900	-	-		OOG6_108991
Panther	1	1.100	-	-	O	PTHR13580
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1316
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.840